INT217388

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.07
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
brain 4
skin 2
adipocytes 2
cortex 2
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 230 99.34 Very High Very High Very High
psoriasis 63 98.90 Very High Very High Very High
Inflammation 85 87.00 High High
withdrawal 25 86.64 High High
Bile 1 81.20 Quite High
Peripheral nervous system 10 68.60 Quite High
Neuritis 48 59.20 Quite High
Central nervous system 9 56.08 Quite High
Pain 6 51.28 Quite High
agonist 10 45.60 Quite Low
Disease Link Frequency Relevance Heat
Psoriasis 106 99.62 Very High Very High Very High
Targeted Disruption 396 99.04 Very High Very High Very High
Disease 222 98.68 Very High Very High Very High
Hyperlipidemia 37 97.96 Very High Very High Very High
Amyloid Plaque 76 97.36 Very High Very High Very High
Obesity 66 96.32 Very High Very High Very High
Disorder Of Lipid Metabolism 72 96.08 Very High Very High Very High
Infection 3 95.84 Very High Very High Very High
Atherosclerosis 75 92.08 High High
Syndrome 42 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As there is limited permeability of the BBB to lipoproteins [14, 128, 129], this change might be due to a decrease of local apoE synthesis and secretion by brain tissue, as part of systemic decrease of apoE synthesis in acute phage reaction [4].
Negative_regulation (decrease) of Gene_expression (synthesis) of apoE in brain
1) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.72 Pain Relevance 0.13
As there is limited permeability of the BBB to lipoproteins [14, 128, 129], this change might be due to a decrease of local apoE synthesis and secretion by brain tissue, as part of systemic decrease of apoE synthesis in acute phage reaction [4].
Negative_regulation (decrease) of Gene_expression (synthesis) of apoE in brain
2) Confidence 0.59 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.77 Pain Relevance 0.12
In humans, decreased expression of apoE caused by some types of genetic disease (Type III hyperlipoproteinaemia associated with familial apolipoprotein E deficiency) leads to an altered lipid profile and an increase in the prevalence of atherosclerosis in these patients [26, 27].
Negative_regulation (decreased) of Gene_expression (expression) of apoE associated with atherosclerosis, hyperlipidemia, disease and disorder of lipid metabolism
3) Confidence 0.57 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2975993 Disease Relevance 0.90 Pain Relevance 0.04
The role of the apoE gene in psoriasis was suggested, because in psoriatic skin there is the downregulation of ApoE expression and the normalization of ApoE levels precedes clinical improvement [67].
Negative_regulation (downregulation) of Gene_expression (expression) of ApoE in skin associated with psoriasis
4) Confidence 0.38 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.18 Pain Relevance 0.12
immunoreactivity were lacking in the cortex in the absence of ApoE expression in animals aged 22 months.
Negative_regulation (absence) of Gene_expression (expression) of ApoE in cortex
5) Confidence 0.33 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.75 Pain Relevance 0.03
It allows the internalization of several ligands such as ApoE, APP (with the Kunitz inhibitor) and ?
Negative_regulation (inhibitor) of Gene_expression (with) of ApoE
6) Confidence 0.33 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.82 Pain Relevance 0.09
Of interest, is the reduced expression of ApoE in the AIM treated cultures, which, by day 21 have mostly differentiated into lipid-filled adipocytes.
Negative_regulation (reduced) of Gene_expression (expression) of ApoE in adipocytes associated with obesity
7) Confidence 0.19 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.16 Pain Relevance 0.24
In contrast, Dex and AIM induced high and robust expression of ApoE, which persisted until the end of the experiment at 21 days.
Negative_regulation (persisted) of Gene_expression (expression) of ApoE associated with dexamethasone
8) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.25
Specifically, MSCs represent an extremely useful tool for the treatment of deficits in ApoE function if harbouring the ApoE ?
Negative_regulation (deficits) of Gene_expression (function) of ApoE
9) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.29 Pain Relevance 0
Ost maintained ApoE expression to day 21, the end point of the experiment, but the levels remained very low.
Negative_regulation (maintained) of Gene_expression (expression) of ApoE
10) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.11 Pain Relevance 0.15
M were sufficient to maintain maximal expression of ApoE, and doses as low as 0.01 ?
Negative_regulation (maintain) of Gene_expression (expression) of ApoE
11) Confidence 0.14 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.36 Pain Relevance 0.23

General Comments

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