INT217389

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2011
Negated 2
Speculated 5
Reported most in Body
Documents 43
Total Number 48
Disease Relevance 18.57
Pain Relevance 3.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
plaques 4
brain 4
peripheral nerves 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 56 99.72 Very High Very High Very High
Inflammation 487 99.56 Very High Very High Very High
Pain 2 99.36 Very High Very High Very High
long-term potentiation 29 96.64 Very High Very High Very High
cINOD 370 96.48 Very High Very High Very High
cytokine 133 94.24 High High
sodium channel 80 92.64 High High
Inflammatory response 85 86.32 High High
antagonist 44 85.52 High High
Hippocampus 206 83.68 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 998 100.00 Very High Very High Very High
Targeted Disruption 1402 99.98 Very High Very High Very High
Amyloid Plaque 335 99.92 Very High Very High Very High
Neurodegenerative Disease 87 99.76 Very High Very High Very High
INFLAMMATION 616 99.56 Very High Very High Very High
Cognitive Disorder 654 99.48 Very High Very High Very High
Pain 2 99.36 Very High Very High Very High
Disease 3251 98.68 Very High Very High Very High
Death 236 97.28 Very High Very High Very High
Disease Progression 106 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although heterozygous knockout also reduced BACE1 expression by ?
Negative_regulation (reduced) of Gene_expression (expression) of BACE1 associated with targeted disruption
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.23 Pain Relevance 0
genotype significantly reduced BACE1 expression (by ?
Negative_regulation (reduced) of Gene_expression (expression) of BACE1
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.07 Pain Relevance 0
deletion lowered BACE1 expression by ?
Negative_regulation (lowered) of Gene_expression (expression) of BACE1
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2944882 Disease Relevance 0.41 Pain Relevance 0
Indeed, the BACE1 promoter is highly conserved between rodents and humans [176, 177] indicating that regulatory mechanisms of BACE1 expression are shared between these species and that rodents represent useful models in which to study mechanisms and to test therapeutics aimed at reducing BACE1 expression.
Negative_regulation (reducing) of Gene_expression (expression) of BACE1
4) Confidence 0.58 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.18 Pain Relevance 0
While Zuchner reported that selective stimulation of M1 muscarininc acetylcholine receptors (mAChRs) increased BACE1 protein expression, with the activation of M2 mAChRs having opposing effects on the level of BACE1 protein [209], Caccamo and colleagues reported an impressive and almost complete inhibition of BACE1 protein expression following treatment of the 3xTg-AD model with a selective M1 muscarinic agonist [210].
Negative_regulation (inhibition) of Gene_expression (expression) of BACE1 protein associated with agonist and disease
5) Confidence 0.58 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.38 Pain Relevance 0.09
We demonstrated that heterozygous gene knockout lowered BACE1 expression by ?
Negative_regulation (lowered) of Gene_expression (expression) of BACE1 associated with targeted disruption
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.51 Pain Relevance 0
and BACE1 elevations, we further examined whether phosphorylation of eIF2?
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (elevations) of BACE1
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.07 Pain Relevance 0
After blocking, membranes were probed with anti-BACE1 (1?
Negative_regulation (blocking) of Gene_expression (probed) of BACE1
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.11 Pain Relevance 0.11
These results indicate a dissociation between C99 and BACE1 levels in the older BACE1+/?
Negative_regulation (dissociation) of Gene_expression (levels) of BACE1
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.24 Pain Relevance 0
Our increasing understanding of BACE1 biology should aid the development of compounds that interfere with BACE1 expression and activity and may lead to the generation of novel therapeutics for AD.



Negative_regulation (interfere) of Gene_expression (expression) of BACE1 associated with disease
10) Confidence 0.43 Published 2007 Journal Current Genomics Section Abstract Doc Link PMC2647160 Disease Relevance 0.93 Pain Relevance 0
A number of strategies were used to achieve inactivation of the BACE1 gene [53-55], and initial data indicated that the absence of BACE1 expression did not appear to adversely affect embryonic development, or significantly affect the morphology, physiology, biochemistry, and gross behavior of post-natal or adult knockout mice [54,55].
Negative_regulation (absence) of Gene_expression (expression) of BACE1 associated with targeted disruption
11) Confidence 0.43 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.25 Pain Relevance 0
agonist pioglitazone reduce BACE1 expression and glial inflammation in APP transgenic mice (Heneka et al., 2005).
Negative_regulation (reduce) of Gene_expression (expression) of BACE1 associated with targeted disruption, inflammation and agonist
12) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.64 Pain Relevance 0.99
agonist pioglitazone reduced glial inflammation and amyloid plaques by decreasing BACE1 expression (Heneka et al., 2005).
Negative_regulation (decreasing) of Gene_expression (expression) of BACE1 in plaques associated with inflammation, agonist and amyloid plaque
13) Confidence 0.42 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.10 Pain Relevance 0.73
burden was not altered in older mice, despite the same decrease in BACE1 levels, indicating that BACE1 is no longer a limiting factor in the aged mouse.
Negative_regulation (decrease) of Gene_expression (levels) of BACE1
14) Confidence 0.42 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.47 Pain Relevance 0
We have recently conducted studies to determine whether BACE1 deficiency, and the consequent ablation of A?
Spec (whether) Negative_regulation (ablation) of Gene_expression (deficiency) of BACE1
15) Confidence 0.42 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.61 Pain Relevance 0.04
While recent studies indicate that complete blockage of BACE1 activity may be associated with certain undesirable side-effects, important data demonstrates that partial reduction of BACE1 levels may improve cognitive deficits and amyloid neuropathology including A?
Spec (partial) Negative_regulation (reduction) of Gene_expression (levels) of BACE1 associated with cognitive disorder and alzheimer's dementia
16) Confidence 0.42 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.80 Pain Relevance 0
Interestingly, an earlier study demonstrated similar findings [98] and our data suggest that the BACE1 elevation occurs in presynaptic neuronal structures around neuritic plaques and that A?
Negative_regulation (occurs) of Gene_expression (elevation) of BACE1 in plaques associated with amyloid plaque
17) Confidence 0.42 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.38 Pain Relevance 0
We recently conducted studies to determine whether BACE1 deficiency, and the consequent ablation of A?
Spec (whether) Negative_regulation (ablation) of Gene_expression (deficiency) of BACE1
18) Confidence 0.42 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.69 Pain Relevance 0.04
These findings suggest that inhibiting the removal of the BACE1 propeptide would not be an effective therapeutic strategy for reducing A?
Negative_regulation (removal) of Gene_expression (propeptide) of BACE1
19) Confidence 0.42 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
However, the age-dependent benefits of partial reduction BACE1 expression appear complex.
Negative_regulation (reduction) of Gene_expression (expression) of BACE1
20) Confidence 0.42 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.43 Pain Relevance 0

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