INT217390

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.95
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
synapses 2
Apoe (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 24 100.00 Very High Very High Very High
aspirin 78 99.68 Very High Very High Very High
Inflammation 57 97.20 Very High Very High Very High
Peripheral nervous system 5 86.80 High High
Thalamus 8 85.88 High High
cINOD 5 75.20 Quite High
cytokine 16 64.44 Quite High
Sciatic nerve 1 60.48 Quite High
Hippocampus 18 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Atherosclerosis 35 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 24 100.00 Very High Very High Very High
Targeted Disruption 190 99.68 Very High Very High Very High
INFLAMMATION 62 97.20 Very High Very High Very High
Stroke 3 88.32 High High
Thrombosis 2 87.88 High High
Myocardial Infarction 2 87.40 High High
Vascular Disease 16 82.28 Quite High
Injury 4 64.96 Quite High
Neointima 1 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ongoing studies in our group have shown a preliminary result of an isotype-specific effect of apoE in EAN, with the most severe clinical course occurring on APOE ?
Negative_regulation (shown) of Positive_regulation (occurring) of APOE associated with neuritis
1) Confidence 0.37 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.53 Pain Relevance 0.52
The importance of ApoE to the trophicity of some synapses appears to be more firmly established, since it is revealed by knocking out the murine gene.
Negative_regulation (established) of Positive_regulation (importance) of ApoE in synapses
2) Confidence 0.33 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.38 Pain Relevance 0.04
NCX 4016, but not ASA, inhibited the initiation of atherosclerotic lesions in carotid arteries of unirradiated ApoE?
Negative_regulation (initiation) of Positive_regulation (arteries) of ApoE associated with aspirin and atherosclerosis
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 1.04 Pain Relevance 0.49

General Comments

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