INT217392

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 2 37.76 Quite Low
antagonist 8 25.12 Quite Low
agonist 8 20.68 Low Low
Hippocampus 47 15.36 Low Low
Inflammation 81 5.00 Very Low Very Low Very Low
Central nervous system 26 5.00 Very Low Very Low Very Low
ischemia 24 5.00 Very Low Very Low Very Low
cytokine 20 5.00 Very Low Very Low Very Low
Peripheral nervous system 20 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 481 100.00 Very High Very High Very High
Neurodegenerative Disease 28 90.96 High High
Alzheimer's Dementia 427 89.60 High High
Aging 18 89.44 High High
Apoptosis 56 89.16 High High
Convulsion 4 78.64 Quite High
Amyloid Plaque 120 70.80 Quite High
Vascular Disease 32 54.36 Quite High
Congenital Anomalies 20 53.60 Quite High
Disease 404 50.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
Negative_regulation (inhibit) of BACE1 Binding (interaction) of
1) Confidence 0.58 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.08 Pain Relevance 0
Of interest are data that indicate that a decrease in cellular cholesterol levels by the cholesterol lowering statin drugs, prevented BACE1 palmitoylation in vitro, which consequently prevented BACE1 dimerization, facilitated a change in the subcellular location of the enzyme and a subsequent reduction in A?
Negative_regulation (prevented) of BACE1 Binding (dimerization) of
2) Confidence 0.50 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0
Conversely, certain molecules have been shown to inhibit the BACE1-APP interaction and thus reduce ?
Negative_regulation (inhibit) of BACE1 Binding (interaction) of
3) Confidence 0.42 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.09 Pain Relevance 0
Some studies found that BACE1 can interact with reticulon/Nogo proteins, whose increased expression can block BACE1 in the ER with a neutral pH environment and thus inhibit BACE1 activity in A?
Negative_regulation (inhibit) of BACE1 Binding (activity) of
4) Confidence 0.41 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.16 Pain Relevance 0
, were abolished in BACE1 knockout brain, unequivocally proving that BACE1 is the major, if not only, ?
Negative_regulation (abolished) of BACE1 Binding (brain) of in brain associated with targeted disruption
5) Confidence 0.37 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.59 Pain Relevance 0
The effect was even spectacular in PDAPP mice heterozygous for BACE1, although the decrease in A?
Negative_regulation (even) of BACE1 Binding (heterozygous) of
6) Confidence 0.24 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.46 Pain Relevance 0
The effect was even spectacular in PDAPP mice heterozygous for BACE1, although the decrease in A?
Negative_regulation (decrease) of BACE1 Binding (heterozygous) of
7) Confidence 0.24 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.45 Pain Relevance 0

General Comments

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