INT217393

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 5.98
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
lung 6
plasma 2
basal layer 2
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 17 97.72 Very High Very High Very High
Inflammation 74 95.72 Very High Very High Very High
pruritus 59 93.20 High High
Nerve growth factor 1 82.92 Quite High
Neuropeptide 14 72.00 Quite High
cytokine 8 63.32 Quite High
Inflammatory response 7 60.48 Quite High
Arthritis 7 58.00 Quite High
Somatostatin 2 46.96 Quite Low
Calcitonin gene-related peptide 7 44.88 Quite Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 616 99.72 Very High Very High Very High
Targeted Disruption 171 97.98 Very High Very High Very High
INFLAMMATION 81 95.72 Very High Very High Very High
Lung Injury 91 93.40 High High
Pruritus 78 93.20 High High
Down Syndrome 8 90.80 High High
Gliosis 2 83.84 Quite High
Psoriasis 60 80.04 Quite High
Vascular Disease 16 78.44 Quite High
Alzheimer's Dementia 160 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of NEP gene expression in the lung tissue of mice with acute lung injury
Negative_regulation (Inhibition) of Gene_expression (expression) of NEP gene in lung associated with adult respiratory distress syndrome
1) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.58 Pain Relevance 0
To determine whether the decrease in lung NEP activity associated with ALI was due to a decrease in the expression of NEP protein in the lung, we measured the NEP protein content in lung homogenates using Western immunoblotting, and found that the expression of NEP protein in the lung in LPS-induced ALI was < 60% of the expression measured under control conditions (Figure 6).


Spec (whether) Negative_regulation (decrease) of Gene_expression (expression) of NEP protein in lung associated with adult respiratory distress syndrome
2) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.56 Pain Relevance 0
The intratracheal instillation of LPS decreased the gene expression of NEP in the lung.
Negative_regulation (decreased) of Gene_expression (expression) of NEP in lung
3) Confidence 0.38 Published 2010 Journal Respir Res Section Abstract Doc Link PMC3009633 Disease Relevance 1.24 Pain Relevance 0
Measurements of NEP activity
Negative_regulation (Measurements) of Gene_expression (activity) of NEP
4) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.12 Pain Relevance 0
The NEP activity measured in the control and the ALI/ARDS groups was 0.22 ± 0.03 and 0.07 ± 0.02 pmol/min/?
Negative_regulation (measured) of Gene_expression (activity) of NEP associated with adult respiratory distress syndrome
5) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.81 Pain Relevance 0
A previous study found that the expression of NEP on circulating PMN was reduced in humans challenged with LPS [40].
Negative_regulation (reduced) of Gene_expression (expression) of NEP
6) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.03 Pain Relevance 0.15
As was observed in patients, the plasma NEP activity was lower in 5 LPS-treated (0.50 ± 0.05 pmol/min/?
Negative_regulation (lower) of Gene_expression (activity) of NEP in plasma
7) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.29 Pain Relevance 0.04
Transgenic mice in which BACE1 has been knocked out or overexpressed have been produced, as well as lines with altered expression of neprilysin, the main degrading enzyme of A?.
Negative_regulation (altered) of Gene_expression (expression) of neprilysin associated with targeted disruption
8) Confidence 0.15 Published 2007 Journal Acta Neuropathol Section Abstract Doc Link PMC2100431 Disease Relevance 1.04 Pain Relevance 0.04
perivascular areas, as well as decreased expression of neutral endopeptidase

(NEP) in the epidermal basal layer and in the endothelia of blood vessels [27].

Negative_regulation (decreased) of Gene_expression (expression) of neutral endopeptidase in basal layer
9) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2221678 Disease Relevance 0.31 Pain Relevance 0.23

General Comments

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