INT2174

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Context Info
Confidence 0.87
First Reported 1979
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 0
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
testes 1
neurons 1
brain 1
PIT 1
ventral 1
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 4 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Enkephalin 12 99.24 Very High Very High Very High
agonist 4 97.64 Very High Very High Very High
antagonist 4 97.12 Very High Very High Very High
Endogenous opioid 1 96.44 Very High Very High Very High
Somatostatin 4 95.88 Very High Very High Very High
narcan 3 95.12 Very High Very High Very High
Dynorphin 2 89.36 High High
Opioid 2 84.88 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that operation of the LHRH pulse generator in the ovariectomized condition is restrained by the action of E2 with the mediation of endogenous opioid peptide neurons.
Protein_catabolism (operation) of LHRH pulse generator in neurons associated with endogenous opioid
1) Confidence 0.87 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 8022518 Disease Relevance 0 Pain Relevance 0.18
The enzyme kinetic parameters of the degradation of luteinizing hormone-releasing hormone (LH-RH) and L-cystine-bis-(4-nitroanilide) (Cys-NA) by rat hypothalamic (HYP) and pituitary (PIT) extracts and the effect of various oligopeptides on the rate of LH-RH inactivation were investigated in vitro.
Protein_catabolism (degradation) of luteinizing hormone-releasing hormone in PIT
2) Confidence 0.80 Published 1979 Journal Neuroendocrinology Section Abstract Doc Link 375117 Disease Relevance 0 Pain Relevance 0
Three applications of the method are described: (a) thyrotropin releasing hormone immunoreactivity in the rat brain has been characterized; (b) ACTH immunoreactivity in the rat pituitary pars intermedia has been resolved into its component peptides; (c) degradation of luteinizing hormone releasing hormone in vitro has been followed.
Protein_catabolism (degradation) of luteinizing hormone in pars intermedia
3) Confidence 0.72 Published 1981 Journal J. Chromatogr. Section Abstract Doc Link 6262333 Disease Relevance 0 Pain Relevance 0.08
Characterization of a soluble LHRH-degrading activity in the rat ventral prostate.
Protein_catabolism (degrading) of LHRH in ventral
4) Confidence 0.65 Published 1993 Journal Prostate Section Title Doc Link 8259344 Disease Relevance 0 Pain Relevance 0.24
Since peptidases able to degrade the hormone are present in several LHRH target structures, it was deemed of interest to investigate whether the prostate of adult normal male rats might possess LHRH degrading activities (LHRH-DA).
Protein_catabolism (degrading) of LHRH-DA
5) Confidence 0.65 Published 1993 Journal Prostate Section Abstract Doc Link 8259344 Disease Relevance 0 Pain Relevance 0.23
TRH, the enkephalin analog [D-Ala2-D-Leu5]enkephalin and rat prolactin do not inhibit the degradation of [pGlu-3H]LHRH by the soluble fraction of prostate homogenate; on the contrary, this is inhibited by graded doses of somatostatin.
Protein_catabolism (degradation) of LHRH associated with somatostatin and enkephalin
6) Confidence 0.65 Published 1993 Journal Prostate Section Abstract Doc Link 8259344 Disease Relevance 0 Pain Relevance 0.34
The degradation of [pGlu-3H]LHRH is inhibited by LHRH itself, and affected by several LHRH agonists and antagonists with different kinetics and potencies.
Protein_catabolism (degradation) of LHRH associated with antagonist and agonist
7) Confidence 0.65 Published 1993 Journal Prostate Section Abstract Doc Link 8259344 Disease Relevance 0 Pain Relevance 0.31
Endopeptidase 24.15 (EP 24.15; EC 3.4.24.15), a zinc-metalloendopeptidase purified from rat brain and testes and also present in many other tissues, including the lung, degrades substance P, neurotensin, bradykinin, luteinizing hormone-releasing hormone, and some other bioactive peptides.
Protein_catabolism (degrades) of hormone-releasing hormone in testes associated with bradykinin and substance p
8) Confidence 0.60 Published 1990 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 2252585 Disease Relevance 0 Pain Relevance 0.31
Endopeptidase 24.15 (EP 24.15; EC 3.4.24.15), a zinc-metalloendopeptidase purified from rat brain and testes and also present in many other tissues, including the lung, degrades substance P, neurotensin, bradykinin, luteinizing hormone-releasing hormone, and some other bioactive peptides.
Protein_catabolism (degrades) of hormone-releasing hormone in brain associated with bradykinin and substance p
9) Confidence 0.20 Published 1990 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 2252585 Disease Relevance 0 Pain Relevance 0.31

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