INT21740

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Context Info
Confidence 0.73
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.46
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC3) extracellular region (TAC3)
Anatomy Link Frequency
arcuate nucleus 1
muscle 1
sensory nerves 1
peripheral nervous systems 1
epithelium 1
TAC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 107 100.00 Very High Very High Very High
Neuropeptide 12 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2 100.00 Very High Very High Very High
Opioid 1 99.74 Very High Very High Very High
Dynorphin 6 99.52 Very High Very High Very High
tetrodotoxin 4 98.96 Very High Very High Very High
qutenza 14 98.92 Very High Very High Very High
Spinal cord 3 94.24 High High
noradrenaline 2 93.94 High High
Inflammation 17 87.76 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 99.50 Very High Very High Very High
Lung Cancer 4 93.28 High High
Hypotension 2 90.88 High High
Hypertrophy 1 89.92 High High
Chronic Disease 1 89.84 High High
Asthma 7 88.40 High High
Reprotox - General 1 2 88.08 High High
INFLAMMATION 20 87.76 High High
Enteropathy 1 86.72 High High
Endometriosis (extended) 3 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All the vasculatures are influenced by neuropeptides released from three types of nerve: (1) sympathetic nerves release both noradrenaline and neuropeptide Y (NPY), both of which cause vasoconstriction; (2) parasympathetic nerves release both acetylcholine and either vasoactive intestinal polypeptide (VIP), peptide histidine methionine (PHM) or peptide histidine isoleucine (PHI), all of which cause vasodilatation; and (3) sensory nerves release sensory neuropeptides such as substance P (SP), calcitonin gene-related peptide (CGRP) and neurokinins A and B (NKA, NKB).
Localization (release) of NKB in sensory nerves associated with noradrenaline, neuropeptide, increased venous pressure under development, calcitonin gene-related peptide and substance p
1) Confidence 0.73 Published 1990 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2196862 Disease Relevance 0.19 Pain Relevance 0.56
In the arcuate nucleus of experimental animals, dynorphin, an opioid peptide, is colocalised with NKB, kisspeptin, ER alpha and progesterone receptors.
Localization (colocalised) of NKB in arcuate nucleus associated with dynorphin and opioid
2) Confidence 0.72 Published 2008 Journal J. Neuroendocrinol. Section Abstract Doc Link 19094085 Disease Relevance 0.34 Pain Relevance 0.15
In a previous study, Pinto et al. showed in a human total mRNA master panel (BD Biosciences Clontech) that TAC1 and TAC3 mRNAs were undetectable in the lung, but they observed a low expression of these transcripts in samples of human bronchi obtained from patients who had undergone lobectomy or pneumectomy for lung carcinoma, a high expression being observed in pulmonary arteries [48].
Localization (undetectable) of TAC3 in lung associated with lung cancer
3) Confidence 0.70 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.09 Pain Relevance 0.11
In contrast to TAC4, we have shown that TAC1, which encodes for SP and NKA, was not detected under our experimental conditions and that TAC3 was observed in only one of four samples.
Localization (observed) of TAC3 associated with substance p
4) Confidence 0.70 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.07 Pain Relevance 0.12
No detectable release of NKB- or NPK-LI was induced by capsaicin.
Localization (release) of NKB associated with qutenza
5) Confidence 0.48 Published 1986 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2430427 Disease Relevance 0.17 Pain Relevance 0.72
The structurally related neuropeptides, substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), which belong to a family of molecules termed tachykinins and are widely distributed in the central and peripheral nervous systems, influence the function of many tissues.
Localization (distributed) of neurokinin B in peripheral nervous systems associated with neuropeptide and substance p
6) Confidence 0.03 Published 1999 Journal Curr. Med. Chem. Section Abstract Doc Link 10101218 Disease Relevance 0.59 Pain Relevance 0.47
To examine if these responses are mediated by different neurokinin receptors, we studied the mechanical response and the release of [3H]acetylcholine from antral muscle strips in response to SP, substance P methylester (SPME), neurokinin A (NKA), neurokinin B (NKB), and several non-mammalian tachykinins.
Localization (release) of neurokinin B in muscle associated with substance p
7) Confidence 0.03 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2462362 Disease Relevance 0 Pain Relevance 0.36
Stimulation of Cl secretion by neurokinin A and neurokinin B in canine tracheal epithelium.
Localization (secretion) of neurokinin B in epithelium associated with neuropeptide
8) Confidence 0.02 Published 1988 Journal Am. Rev. Respir. Dis. Section Title Doc Link 2833141 Disease Relevance 0 Pain Relevance 0.10

General Comments

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