INT217438

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 7.29
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 145 99.48 Very High Very High Very High
Inflammation 229 99.08 Very High Very High Very High
cINOD 21 96.04 Very High Very High Very High
Inflammatory response 85 84.88 Quite High
rheumatoid arthritis 2 72.28 Quite High
chemokine 100 63.56 Quite High
Nerve growth factor 4 41.88 Quite Low
Inflammatory stimuli 2 39.44 Quite Low
Paracetamol 6 13.36 Low Low
fibrosis 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 459 99.76 Very High Very High Very High
INFLAMMATION 334 99.08 Very High Very High Very High
Frontotemporal Dementia 2 97.04 Very High Very High Very High
Hepatocellular Cancer 142 96.96 Very High Very High Very High
Bone Disease 51 95.92 Very High Very High Very High
Muscle Disease 2 95.12 Very High Very High Very High
Targeted Disruption 40 94.76 High High
Cancer 165 94.72 High High
Liver Cancer 9 94.60 High High
Sprains And Strains 100 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Once activated, TAK1 activates the IKK complex and eventually activates NF-?
IKK Binding (complex) of
1) Confidence 0.25 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.06 Pain Relevance 0
Recently, IKK?
IKK Binding (Recently) of
2) Confidence 0.22 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.12 Pain Relevance 0.07
To determine the role of JNK in these models, JNK1-deficient mice were interbred with Ikk?
Ikk Binding (interbred) of
3) Confidence 0.22 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.95 Pain Relevance 0.07
B; RANK-L, RANK-ligand; OPG, osteoprotogerin; VCP, valosin-containing protein; UPS, ubiquitin proteasome system; IKKß, I-?
IKK Binding (ligand) of
4) Confidence 0.16 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.12 Pain Relevance 0.08
In keeping with our hypothesis, both pharmacological and dominant negative molecular inhibitions of the IKK?
IKK Binding (keeping) of
5) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.15 Pain Relevance 0.03
was needed for B14 to be part of the IKK complex.
IKK Binding (complex) of
6) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Upon stimulation, the IKK complex phosphorylates I?
IKK Binding (complex) of
7) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
The IKK complex, or signalosome, comprises a heterodimer of IKK?
IKK Binding (complex) of
8) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.62 Pain Relevance 0.27
Furthermore, B14 associated with the IKK complex via IKK?
IKK Binding (complex) of
9) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
However, three independent experiments shown here contradict this: first, N1 did not bind to IKK components in the LUMIER assay (Figure 2B); second, N1 did not co-purify with IKK during biochemical fractionation of infected cells (Figure 2C); and third, N1 did not co-precipitate with IKK components using the anti-NEMO mAb (unpublished data).
IKK Neg (not) Binding (bind) of
10) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
The IKK complex is critical for activation of NF-?
IKK Binding (complex) of
11) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.54 Pain Relevance 0.18
Components of the IKK complex were included in the assay because several pathways leading to NF-?
IKK Binding (complex) of
12) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
The activity of the immunoprecipitated IKK complex was studied using a synthetic I?
IKK Binding (complex) of
13) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.33 Pain Relevance 0
Therefore, B14, but not N1, associates with the IKK complex and thereby inhibits NF-?
IKK Binding (complex) of
14) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.08 Pain Relevance 0
The interaction between B14 and IKK?
IKK Binding (interaction) of
15) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
The IKK complex is activated by upstream kinases, such as transforming growth factor-?
IKK Binding (complex) of
16) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.58 Pain Relevance 0.26
The possible interaction between B14 and the IKK complex was investigated further by immunoprecipitation.
IKK Binding (interaction) of
17) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.09 Pain Relevance 0
is necessary for B14 to co-purify or co-precipitate with the IKK complex.


IKK Binding (precipitate) of
18) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
B14 only co-purified with the IKK complex of 700–900 kDa when IKK?
IKK Binding (complex) of
19) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
To investigate whether the endogenous levels of B14 could affect IKK activity during virus infection, the phosphorylation status of I?
IKK Binding (activity) of associated with infection
20) Confidence 0.10 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.31 Pain Relevance 0

General Comments

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