INT21744

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Context Info
Confidence 0.12
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.47
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 2
amygdala 2
crf (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 8 100.00 Very High Very High Very High
Endogenous opioid 3 99.80 Very High Very High Very High
abdominal pain 4 98.60 Very High Very High Very High
Locus ceruleus 3 97.92 Very High Very High Very High
medulla 27 90.24 High High
Thalamus 2 87.84 High High
narcan 2 87.40 High High
antagonist 11 87.04 High High
opiate 5 86.24 High High
Nicotine 2 79.28 Quite High
Disease Link Frequency Relevance Heat
Stress 10 99.98 Very High Very High Very High
Abdominal Pain 4 98.60 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.24 Very High Very High Very High
Pallor 1 96.84 Very High Very High Very High
Vomiting 107 96.52 Very High Very High Very High
Hypertension 4 95.68 Very High Very High Very High
Heart Rate Under Development 5 95.12 Very High Very High Very High
Pheochromocytoma 2 91.52 High High
Anxiety Disorder 28 84.48 Quite High
Obesity 57 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of CRF and bombesin-like peptides in the amygdala is markedly increased by both stress and feeding [179].
Positive_regulation (increased) of Localization (release) of CRF in amygdala associated with stress and amygdala
1) Confidence 0.12 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.55 Pain Relevance 0.58
We conclude that the unexpected inhibitory effects of NMA on LH secretion in the adult ovariectomized monkey are the result of the activation of the hypothalamic-pituitary-adrenal axis by NMA and specifically of the release of CRF and endogenous opioid peptides.
Positive_regulation (activation) of Localization (release) of CRF in pituitary associated with endogenous opioid
2) Confidence 0.04 Published 1990 Journal Endocrinology Section Abstract Doc Link 2197080 Disease Relevance 0 Pain Relevance 0.27
Stress induces hypothalamic release of Corticotropin Releasing Factor (CRF) [60].
Positive_regulation (induces) of Localization (release) of CRF associated with stress
3) Confidence 0.03 Published 2005 Journal BMC Med Section Body Doc Link PMC1326207 Disease Relevance 2.92 Pain Relevance 0.62

General Comments

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