INT217464

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.28
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Traf6) protein complex (Traf6) ligase activity (Traf6)
cytoplasm (Traf6) signal transducer activity (Traf6) cytosol (Traf6)
Anatomy Link Frequency
osteoclasts 1
Traf6 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 96.76 Very High Very High Very High
Inflammation 77 95.64 Very High Very High Very High
rheumatoid arthritis 74 87.72 High High
Nerve growth factor 8 81.84 Quite High
cytokine 56 54.32 Quite High
Paracetamol 2 17.76 Low Low
Arthritis 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 71 98.00 Very High Very High Very High
INFLAMMATION 86 95.64 Very High Very High Very High
Bone Disease 102 92.72 High High
Systemic Lupus Erythematosus 62 91.12 High High
Rheumatoid Arthritis 74 87.72 High High
Syndrome 18 69.92 Quite High
Liver Disease 4 50.40 Quite High
Arthritis 19 38.28 Quite Low
Apoptosis 20 35.84 Quite Low
Autoimmune Disease 25 33.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, directly interfering with the p62-TRAF6 interaction using a short peptide equivalent to the TRAF-binding domain sequence of p62, offers the possibility of selectively targeting TRAF6-mediated NF-?
TRAF6 Binding (interaction) of
1) Confidence 0.29 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.65 Pain Relevance 0.10
B signalling pathway are not fully established, key steps (some with known dependence upon ubiquitylation) include (see Figure 1): engagement of RANK by RANK-L, which is antagonised by OPG-RANK-L binding; association of TRAF6 with activated RANK; binding of p62 to TRAF6; Lys63-linked autoubiquitylation of TRAF6, catalysed by its intrinsic E3 ubiquitin ligase activity; p62-aPKC-mediated phosphorylation and activation of I-?
TRAF6 Binding (binding) of associated with addiction
2) Confidence 0.28 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05
IRAK4 in turn phosphorylates IRAK1, and IRAK2 promotes their association with TRAF6, which serves as a platform to recruit TAK1 kinase.
TRAF6 Binding (association) of
3) Confidence 0.19 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.05 Pain Relevance 0
Briefly, IRAK4 is a kinase that interacts with MyD88 and TRAF6 and is associated with the activation of the downstream transcription factors in TLR signaling.
TRAF6 Binding (interacts) of
4) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2945668 Disease Relevance 0.24 Pain Relevance 0.05
In essence, RANK and RANKL are trimeric molecules; upon ligand binding multiple TRAFs are recruited, with TRAF6 being the critical adaptor as its absence incapacitates osteoclasts [147,148].
TRAF6 Binding (recruited) of in osteoclasts
5) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.35 Pain Relevance 0.15

General Comments

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