INT21747

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 5.32
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
pituitary 1
amygdala 1
crf (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 11 99.82 Very High Very High Very High
Endogenous opioid 3 99.80 Very High Very High Very High
IPN 2 99.36 Very High Very High Very High
opioid receptor 2 99.20 Very High Very High Very High
amygdala 10 98.60 Very High Very High Very High
Locus ceruleus 3 97.92 Very High Very High Very High
abdominal pain 4 97.76 Very High Very High Very High
Inflammation 7 97.32 Very High Very High Very High
Opioid 10 96.48 Very High Very High Very High
Analgesic 3 94.44 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 99.82 Very High Very High Very High
Stress 10 99.56 Very High Very High Very High
Inflammatory Pain 2 99.36 Very High Very High Very High
Abdominal Pain 4 97.76 Very High Very High Very High
INFLAMMATION 7 97.32 Very High Very High Very High
Increased Venous Pressure Under Development 2 96.40 Very High Very High Very High
Pallor 1 96.00 Very High Very High Very High
Vomiting 107 95.68 Very High Very High Very High
Hypertension 4 94.84 High High
Heart Rate Under Development 5 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The release of prodynorphin-derived peptides paralleled secretion of endogenous proopiomelanocortin-derived peptides when stimulated by CRF, a natural secretagogue for ACTH.
Localization (secretagogue) of CRF
1) Confidence 0.47 Published 1989 Journal Mol. Endocrinol. Section Abstract Doc Link 2575215 Disease Relevance 0 Pain Relevance 0.19
These endogenous substances can be released by "releasing factors" such as CRF and IL-4 via activation of their receptors on the cell surface of inflammatory cells.
Localization (released) of CRF associated with inflammation
2) Confidence 0.29 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 12617563 Disease Relevance 0.41 Pain Relevance 0.95
Locally expressed CRF but not IL-1 appear to trigger this release.
Localization (release) of CRF
3) Confidence 0.29 Published 2003 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 12617563 Disease Relevance 0.65 Pain Relevance 1.09
The release of CRF and bombesin-like peptides in the amygdala is markedly increased by both stress and feeding [179].
Localization (release) of CRF in amygdala associated with stress and amygdala
4) Confidence 0.18 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.52 Pain Relevance 0.58
This suggests that DAMME may inhibit endogenous CRF release by an action at hypothalamic level or above.
Localization (release) of CRF
5) Confidence 0.12 Published 1985 Journal Horm. Metab. Res. Section Abstract Doc Link 3002932 Disease Relevance 0 Pain Relevance 0.30
We conclude that the unexpected inhibitory effects of NMA on LH secretion in the adult ovariectomized monkey are the result of the activation of the hypothalamic-pituitary-adrenal axis by NMA and specifically of the release of CRF and endogenous opioid peptides.
Localization (release) of CRF in pituitary associated with endogenous opioid
6) Confidence 0.06 Published 1990 Journal Endocrinology Section Abstract Doc Link 2197080 Disease Relevance 0 Pain Relevance 0.27
Stress induces hypothalamic release of Corticotropin Releasing Factor (CRF) [60].
Localization (release) of CRF associated with stress
7) Confidence 0.05 Published 2005 Journal BMC Med Section Body Doc Link PMC1326207 Disease Relevance 2.80 Pain Relevance 0.62
CeA(M)-PAG neurons hyperpolarized by N/OFQ express CRF or neurotensin mRNA.
Localization (hyperpolarized) of CRF in neurons associated with central grey
8) Confidence 0.05 Published 2009 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18930828 Disease Relevance 0.94 Pain Relevance 1.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox