INT217470

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Traf6, Ngf) protein complex assembly (Traf6) protein complex (Traf6)
ligase activity (Traf6) cytoplasm (Traf6) signal transducer activity (Traf6)
Anatomy Link Frequency
neurite 1
Traf6 (Mus musculus)
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 4 100.00 Very High Very High Very High
cytokine 3 44.56 Quite Low
rheumatoid arthritis 2 34.80 Quite Low
Inflammation 1 19.28 Low Low
addiction 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 15 88.24 High High
Bone Disease 51 82.96 Quite High
Syndrome 9 60.16 Quite High
Hypercalcemia 4 42.96 Quite Low
Osteoporosis 4 37.76 Quite Low
Rheumatoid Arthritis 2 34.80 Quite Low
Apoptosis 1 26.08 Quite Low
INFLAMMATION 1 19.28 Low Low
Osteogenic Sarcomas 3 5.00 Very Low Very Low Very Low
Osteolysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the case of NGF signalling (which also depends upon TRAF6 and p62), this approach was recently used in cultured cells to inhibit NGF-induced neurite outgrowth, a process dependent on TRAF6-p62-mediated NF-?
TRAF6 Positive_regulation (depends) of NGF in neurite associated with nerve growth factor
1) Confidence 0.36 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.52 Pain Relevance 0.10

General Comments

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