INT217472

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nup62, Mul1) nucleus (Nup62, Mul1) mitochondrion (Mul1)
transport (Nup62) nuclear envelope (Nup62) peroxisome (Mul1)
Nup62 (Mus musculus)
Mul1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 94.88 High High
cytokine 3 11.40 Low Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 51 31.72 Quite Low
Osteogenic Sarcomas 3 31.36 Quite Low
Osteoporosis 4 30.24 Quite Low
Syndrome 9 27.52 Quite Low
Disease 15 5.00 Very Low Very Low Very Low
Hypercalcemia 4 5.00 Very Low Very Low Very Low
Osteolysis 2 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Muscle Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B signalling pathway are not fully established, key steps (some with known dependence upon ubiquitylation) include (see Figure 1): engagement of RANK by RANK-L, which is antagonised by OPG-RANK-L binding; association of TRAF6 with activated RANK; binding of p62 to TRAF6; Lys63-linked autoubiquitylation of TRAF6, catalysed by its intrinsic E3 ubiquitin ligase activity; p62-aPKC-mediated phosphorylation and activation of I-?
p62 Binding (activity) of E3 ubiquitin ligase associated with addiction
1) Confidence 0.12 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05

General Comments

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