INT217478

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.22
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Traf6) protein complex (Traf6) ligase activity (Traf6)
cytoplasm (Traf6) signal transducer activity (Traf6) cytosol (Traf6)
Tnfrsf11a (Mus musculus)
Traf6 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 4 97.60 Very High Very High Very High
cytokine 12 57.52 Quite High
Pain 4 35.28 Quite Low
rheumatoid arthritis 8 13.76 Low Low
Nerve growth factor 16 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 204 91.68 High High
Disease 60 77.48 Quite High
Infection 4 68.60 Quite High
Syndrome 36 67.32 Quite High
Frontotemporal Dementia 8 64.76 Quite High
Muscle Disease 8 62.84 Quite High
Osteolysis 8 52.76 Quite High
Osteogenic Sarcomas 12 45.04 Quite Low
Spontaneous Fractures 4 39.40 Quite Low
Deafness 4 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RANK is a member of the TNF receptor family [11] that, upon engagement of RANK-ligand (RANK-L), directly interacts with TRAF6, leading to downstream activation of several signalling pathways including an NF-?
RANK Binding (interacts) of TRAF6
1) Confidence 0.39 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.22 Pain Relevance 0.03
B signalling pathway are not fully established, key steps (some with known dependence upon ubiquitylation) include (see Figure 1): engagement of RANK by RANK-L, which is antagonised by OPG-RANK-L binding; association of TRAF6 with activated RANK; binding of p62 to TRAF6; Lys63-linked autoubiquitylation of TRAF6, catalysed by its intrinsic E3 ubiquitin ligase activity; p62-aPKC-mediated phosphorylation and activation of I-?
RANK Binding (association) of TRAF6 associated with addiction
2) Confidence 0.31 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05
B signalling pathway are not fully established, key steps (some with known dependence upon ubiquitylation) include (see Figure 1): engagement of RANK by RANK-L, which is antagonised by OPG-RANK-L binding; association of TRAF6 with activated RANK; binding of p62 to TRAF6; Lys63-linked autoubiquitylation of TRAF6, catalysed by its intrinsic E3 ubiquitin ligase activity; p62-aPKC-mediated phosphorylation and activation of I-?
RANK Binding (association) of TRAF6 associated with addiction
3) Confidence 0.31 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05
B signalling pathway are not fully established, key steps (some with known dependence upon ubiquitylation) include (see Figure 1): engagement of RANK by RANK-L, which is antagonised by OPG-RANK-L binding; association of TRAF6 with activated RANK; binding of p62 to TRAF6; Lys63-linked autoubiquitylation of TRAF6, catalysed by its intrinsic E3 ubiquitin ligase activity; p62-aPKC-mediated phosphorylation and activation of I-?
RANK Binding (binding) of TRAF6 associated with addiction
4) Confidence 0.31 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.05

General Comments

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