INT217500

Context Info Confidence 0.24 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.96 Pain Relevance 0.13

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 8 90.92 Inflammation 20 55.68 cytokine 4 54.12 Versed 4 5.00 tetrodotoxin 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Colitis 62 97.66 Disease 8 90.92 Weight Loss 4 89.28 Gastrointestinal Disease 8 75.32 Inflammatory Bowel Disease 34 66.36 INFLAMMATION 18 55.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 10 19.88 Injury 2 18.16 Infection 8 17.88 Diarrhoea 14 16.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].

Phosphorylation (phosphorylation) of occludin associated with colitis

1) Confidence 0.24 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07

This hypothesis is also supported by a recent study demonstrating that probiotic Streptococcus thermophilus and Lactobacillus acidophilus can prevent invasion of enteroinvasive E. coli and enhance intestinal epithelial barrier function by amplifying phosphorylation of occludin and ZO-1 in vitro [19].

Phosphorylation (phosphorylation) of occludin

2) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.19 Pain Relevance 0.05

General Comments

This test has worked.