INT217507

Context Info Confidence 0.57 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.65 Pain Relevance 0.13

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Anatomy Link Frequency endothelial cells 1 podocytes 1 Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 4 98.24 addiction 1 90.84 fibrosis 1 43.48 anesthesia 10 5.00 Inflammation 10 5.00 imagery 5 5.00 Central nervous system 3 5.00 cytokine 2 5.00 agonist 2 5.00 Versed 2 5.00

Disease Link Frequency Relevance Heat Colitis 31 98.64 Disease 20 98.24 Targeted Disruption 77 95.08 Inflammatory Bowel Disease 17 78.12 Weight Loss 2 64.80 Focal Segmental Glomerulosclerosis 6 64.24 Renal Disease 3 59.44 Arrhythmia Under Development 19 58.96 Metastasis 25 50.00 Adhesions 9 45.24

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, a study described the translocation of ZO-1 from the apical to the basolateral side in CD patients [53] indicating an alteration of ZO-1 under pathological conditions.

Localization (translocation) of ZO-1 associated with crohn's disease

1) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.76 Pain Relevance 0.08

Therefore, we examined the effects of PCB treatment on the localization profiles of claudin-5, occludin, and ZO-1 in freshly isolated microvessels (Figures 2 and 3).

Localization (localization) of ZO-1

2) Confidence 0.14 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

On a molecular level, the functional interaction of gap and tight junction is supported by coprecipitation and colocalization of Cx40 and Cx43 with tight junction molecules occludin, claudin-5, and ZO-1 in endothelial cells (25).

Localization (colocalization) of ZO-1 in endothelial cells

3) Confidence 0.14 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.77 Pain Relevance 0.05

Moreover, podocalyxin, a marker protein of the apical domains of podocytes [23], localized not only in the apical but also in the basal domains, whereas ZO-1 localized at the irregular cell–cell junctions (Figure 4B), indicating disturbance in the apico-basal cell polarity.

Localization (localized) of ZO-1 in podocytes

4) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614475 Disease Relevance 0.12 Pain Relevance 0

Interestingly, some internalized dextran at MCJs colocalizes with internalized E-cadherin as well as ZO-1, a scaffolding protein associated with the TJs in polarized cells (Figure 3E) [70].

Localization (colocalizes) of ZO-1

5) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0 Pain Relevance 0

General Comments

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