INT217508

Context Info Confidence 0.30 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.77 Pain Relevance 0.07

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1) cytoplasm (Tjp1)

Tjp1 (Mus musculus)

Pain Link Frequency Relevance Heat Crohn's disease 4 91.40 Inflammation 10 5.00 cytokine 2 5.00 Versed 2 5.00 tetrodotoxin 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Colitis 31 97.90 Disease 4 91.40 Weight Loss 2 89.28 Inflammatory Bowel Disease 17 66.84 Injury 1 18.16 INFLAMMATION 9 5.00 Diarrhoea 7 5.00 Body Weight 7 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 5 5.00 Gastrointestinal Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, using a mouse colitis model, Resta-Lenert et al. have shown that the increase in intestinal permeability is associated with a decrease of occludin and ZO-1 phosphorylation [54].

Negative_regulation (decrease) of Phosphorylation (phosphorylation) of ZO-1 associated with colitis

1) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.77 Pain Relevance 0.07

General Comments

This test has worked.