INT217510

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.53
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cells 2
covering 1
Dss1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 116 90.16 High High
Lasting pain 14 70.92 Quite High
Opioid 61 69.84 Quite High
Pain management 6 58.96 Quite High
Analgesic 4 41.48 Quite Low
Pain 19 29.56 Quite Low
addiction 4 7.52 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Piles 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 85 98.24 Very High Very High Very High
INFLAMMATION 109 90.16 High High
Hemorrhage 13 88.88 High High
Body Weight 7 74.04 Quite High
Pain 36 70.92 Quite High
Disease 16 60.84 Quite High
Diarrhoea 13 36.24 Quite Low
Toxicity 3 32.40 Quite Low
Drug Dependence 2 31.64 Quite Low
Hypertension 3 14.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included: automatic delivery, presentation of the DSS when and where clinical decision making occurs, provision of concrete recommendations of how to proceed, and computer-based generation of decision support [18].
Localization (presentation) of DSS
1) Confidence 0.49 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.18 Pain Relevance 0.30
DSS with all its sulfate groups are acidic in nature and one can speculate that the DSS effect on colon mucus could be similar to the pore forming effect of acid secreted from the stomach glands in the inner mucus layer covering the stomach epithelium [22].
Localization (secreted) of DSS in covering
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.43 Pain Relevance 0.05
This suggests that the epithelium with its mucus secreting goblet cells is functional and secretes a mucus layer of normal thickness after 24 h DSS administration.
Localization (secretes) of DSS in epithelium
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.06 Pain Relevance 0.03
Thus we conclude that the epithelial cells seem to be functional and that they secrete a normal mucus layer after 24 h or less of DSS treatment.
Localization (secrete) of DSS in epithelial cells
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.43 Pain Relevance 0.11
Although ZO-2 mRNA was not up-regulated by EcN under healthy conditions, a slight increase of ZO-2 mRNA could be detected in DSS mice treated with EcN (data not shown).
Localization (treated) of DSS
5) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.43 Pain Relevance 0.10

General Comments

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