INT217514

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 17
Disease Relevance 7.60
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
feces 1
colon 1
proximal 1
epithelium 1
bowels 1
Dss1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 357 99.76 Very High Very High Very High
withdrawal 12 92.24 High High
Crohn's disease 46 90.80 High High
Lasting pain 14 70.92 Quite High
Opioid 61 69.84 Quite High
imagery 27 63.56 Quite High
Pain management 6 58.96 Quite High
cytokine 67 43.72 Quite Low
Analgesic 4 41.48 Quite Low
Pain 19 29.56 Quite Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
INFLAMMATION 341 99.76 Very High Very High Very High
Colitis 334 99.64 Very High Very High Very High
Urological Neuroanatomy 12 99.46 Very High Very High Very High
Body Weight 52 97.24 Very High Very High Very High
Disease 97 95.64 Very High Very High Very High
Hemorrhage 42 94.24 High High
Mucositis 5 82.96 Quite High
Inflammatory Bowel Disease 250 81.84 Quite High
Pressure And Volume Under Development 6 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included: automatic delivery, presentation of the DSS when and where clinical decision making occurs, provision of concrete recommendations of how to proceed, and computer-based generation of decision support [18].
Gene_expression (presentation) of DSS
1) Confidence 0.47 Published 2010 Journal Implement Sci Section Body Doc Link PMC2868045 Disease Relevance 0.18 Pain Relevance 0.30
This mucus was secreted without being exposed to DSS, further supporting that the initial effects of DSS is on the mucus itself.
Neg (without) Gene_expression (exposed) of DSS
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.54 Pain Relevance 0.13
In vivo measurements of the firm mucus were performed as described previously on animals subjected to 3% DSS in the drinking water for 24 h (n?
Gene_expression (described) of DSS
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0 Pain Relevance 0.06
The epithelium producing the mucus is not affected by short DSS exposure
Gene_expression (exposure) of DSS in epithelium
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.25 Pain Relevance 0.12
The changes in mucus properties triggered by DSS allowed bacteria to penetrate
Gene_expression (triggered) of DSS
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.08 Pain Relevance 0.04
In fact, this is supported by the immunohistochemistry pictures showing that the typical stratified lamellar appearance of the inner mucus layer was lost after DSS exposure.
Gene_expression (exposure) of DSS
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.20 Pain Relevance 0.03
No signs of inflammation with short DSS exposure
Gene_expression (exposure) of DSS associated with inflammation
7) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923597 Disease Relevance 0.25 Pain Relevance 0.12
MPO values were significantly higher in DSS-treated groups than corresponding controls at all the periods studied.
Gene_expression (higher) of DSS associated with urological neuroanatomy
8) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.87 Pain Relevance 0.18
Combined with the absorptive Na+ flux in these animals, this is likely to explain the nearly normal appearance of the feces in the DSS plus EcN treated mice compared to the liquid stools of the mice with DSS colitis.
Gene_expression (feces) of DSS in feces associated with colitis
9) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.60 Pain Relevance 0.03
Finally, EcN provides protection against the DSS-mediated leakiness of the gut in our mouse model.
Gene_expression (protection) of DSS in gut
10) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.45 Pain Relevance 0
In addition, we observed an altered ZO-1 expression profile in IECs of mice with DSS-induced colitis.
Gene_expression (expression) of DSS associated with colitis
11) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.76 Pain Relevance 0.08
In contrast, in DSS and EcN treated mice (group III), this colon shortening was significantly attenuated with 7.5 (±1.5) cm (p<0.05) (Figure 4B).
Gene_expression (attenuated) of DSS in colon
12) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 1.05 Pain Relevance 0.10
After 5 days of DSS administration, the mice resumed drinking plain water, and mice were administered oral doses of IO (20?
Gene_expression (administration) of DSS
13) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 0.45 Pain Relevance 0
The amount of consumed DSS was approximately 40?
Gene_expression (amount) of DSS
14) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 0.45 Pain Relevance 0
However, an alternative explanation is that ASF/SF2 requires the U2AF65 consensus sequence adjacent to exon 8a to be present in order for it to bind to consensus sequences downstream and repress distal splice site selection, and hence when mutated or deleted DSS repression is lifted resulting in preferential proximal splice site selection.
Gene_expression (repression) of DSS in proximal associated with repression
15) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.15 Pain Relevance 0
The PEO treatments significantly suppressed DSS-induced colitis in acute as well as chronic models, improving their body weights and stool consistency, as well as decreasing their intestinal bleeding (combined together as DAI, Fig 1).
Gene_expression (suppressed) of DSS in body associated with colitis, body weight and hemorrhage
16) Confidence 0.03 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 1.22 Pain Relevance 0.11
Qualitative differences were widespread among the bowels of both the PEO (Fig 2E) and 5-ASA (Fig 2F) groups relative to the DSS group (Fig 2D).
Gene_expression (group) of DSS in bowels
17) Confidence 0.03 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.09 Pain Relevance 0.04

General Comments

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