INT217515

Context Info Confidence 0.22 First Reported 2007 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 7 Total Number 8 Disease Relevance 2.12 Pain Relevance 0.25

cytosol (Ocln) structural molecule activity (Ocln) plasma membrane (Ocln)

Anatomy Link Frequency tail 1 filaments 1 Fundus 1 Ocln (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 5 97.24 cytokine 2 95.20 Inflammation 10 92.32 agonist 2 87.84 Crohn's disease 4 59.08 Inflammatory mediators 2 47.12 Central nervous system 6 27.52 Neurobehavioral 2 10.92 anesthesia 8 5.00 ketamine 5 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 11 92.32 Inflammatory Bowel Disease 17 90.24 Cancer 52 88.96 Apoptosis 145 87.20 Ganglion Cysts 65 84.72 Gastrointestinal Disease 4 84.40 Death 10 84.16 Congenital Anomalies 10 82.12 Diabetic Angiopathy 5 73.48 Acquired Immune Deficiency Syndrome Or Hiv Infection 5 70.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For example, binding of zo-1 to the COOH-terminal cytoplasmic tail of occludin plays a role in maintaining the tight junction and also cytoskeletal tethering [48], whereas previous studies describe the association of occludin/zo-1 as dependent upon both tyrosine phosphatase signaling and also protein kinase C [49].

occludin Binding (association) of in tail associated with kinase c

1) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.37 Pain Relevance 0.05

Immunoprecipitation of occludin followed by western blotting for zo-1 revealed that coculture of EC with 10T1/2 cells led to an increased association between occludin and zo-1 in EC, which was significantly reduced by TGF-?

occludin Binding (association) of

2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.05 Pain Relevance 0

In concordance with these observations in vivo, coculture of ECs and 10T1/2 cells led to enhanced EC barrier function, and the addition of the ALK5 inhibitor reversed this effect and reduced coculture-induced association between occludin and zo-1.

occludin Binding (association) of

3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.24 Pain Relevance 0

Changes in occludin/zo-1 co-association were monitored by immunoprecipitation, performed as previously described [53] with minor modifications.

occludin Binding (association) of

4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0 Pain Relevance 0

Fundus angiography and Evans blue permeability assay revealed a breakdown of the blood-retinal-barrier that was characterized by decreased association between the tight junction proteins zo-1 and occludin.

occludin Binding (association) of in Fundus

5) Confidence 0.14 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2659748 Disease Relevance 0.17 Pain Relevance 0

This molecule constitutes the structural link between the cytoskeleton and the tight junction by binding to both actin filaments and the TJ protein occludin [6].

occludin Binding (binding) of in filaments

6) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 1.21 Pain Relevance 0.15

Exposure to PCB118 and PCB153 modulated expressional levels of claudin-5 and ZO-1, whereas PCB126 appeared to primarily influence the coassociation of occludin and ZO-1.

occludin Spec (appeared) Binding (coassociation) of

7) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0.06 Pain Relevance 0.04

The enhanced interaction between ZO-1 and occludin appeared to be most pronounced in cerebral microvessels of PCB126-treated animals, followed by the PCB153 treatment group.

occludin Spec (appeared) Binding (interaction) of

8) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854723 Disease Relevance 0 Pain Relevance 0

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