INT217525

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.90
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SMPD2) plasma membrane (SMPD2)
Anatomy Link Frequency
epithelium 2
plasma 1
sieves 1
HeLa 1
SMPD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 24 96.04 Very High Very High Very High
Inflammation 12 63.92 Quite High
cytokine 2 45.44 Quite Low
peptic ulcer disease 6 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 22 99.36 Very High Very High Very High
Polyploidy 1 97.50 Very High Very High Very High
Poisoning 60 96.64 Very High Very High Very High
Colitis 31 91.68 High High
Alagille Syndrome 18 84.56 Quite High
Lifespan 82 78.92 Quite High
Intestinal Cancer 14 78.40 Quite High
Cleidocranial Dysplasia 23 66.24 Quite High
INFLAMMATION 12 63.92 Quite High
Diarrhoea 7 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ISC-4 was synthesized following a method recently developed by Sharma et al. [65] Briefly, a solution of triphosgene (1.48 g, 5.0 mmol) in CH2Cl2 (15 mL) was added dropwise, for a period of 1 h, to a refluxing mixture of phenylbutyl formamide (1.77 g, 10.0 mmol), triethylamine (4.35 g, 6.0 mL, 43.0 mmol) and 4Å molecular sieves in CH2Cl2 (50 mL).
Gene_expression (synthesized) of ISC in sieves
1) Confidence 0.75 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.05 Pain Relevance 0
This increase is accompanied by a progressive accumulation of polyploid, mis-differentiated cells that accumulate at the basal membrane of the epithelium and can be visualized by their continuous expression of the ISC/EB marker escargot (esg; [42], [43], [54]).
Gene_expression (expression) of ISC in epithelium associated with polyploidy
2) Confidence 0.75 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954830 Disease Relevance 0.62 Pain Relevance 0
To evaluate secretory and absorptive function of the colonic epithelium, we measured the basal and forskolin-stimulated Isc (which is an assessment of the electrogenic anion secretion, and its stimulation by an increase in intracellular cAMP levels), as well as net Na+ absorption before and after an increase in cAMP levels.
Gene_expression (absorption) of Isc in epithelium
3) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.53 Pain Relevance 0.06
Several studies have indicated that H. pylori produces a SMase in vitro [62],[63].
Gene_expression (produces) of SMase
4) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.16 Pain Relevance 0
Currently it is unknown whether the H. pylori SMase is produced in vivo during infection, and if so, whether it is present at concentrations sufficient to deplete plasma membrane SM of gastric cells in vivo.
Gene_expression (produced) of SMase in plasma associated with infection
5) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.17 Pain Relevance 0
Recombinant SMase D [34] and Venus-lysenin [47] were expressed and purified as previously described in refs [65], and [47], respectively.


Gene_expression (expressed) of SMase
6) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.14 Pain Relevance 0
In contrast, adding exogenous PC, PE, PI, or cholesterol back to HeLa cells that had been preincubated with SMase did not restore cellular sensitivity to VacA, even at very high concentrations of lipids (200 ?
Gene_expression (preincubated) of SMase in HeLa
7) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0 Pain Relevance 0
Moreover, we determined that SMase C pretreatment inhibited VacA-mediated cellular vacuolation to the same extent in the presence or absence of the PKC inhibitor, BIM I (0 – 5 ?
Gene_expression (pretreatment) of SMase associated with kinase c
8) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.14 Pain Relevance 0.18
We also evaluated whether contaminating phospholipase C (PLC) activity within our SMase preparations might contribute to the inhibition of vacuolation.
Gene_expression (preparations) of SMase
9) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.10 Pain Relevance 0.11

General Comments

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