INT21756

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.21
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) enzyme binding (Alb) DNA binding (Alb)
protein complex (Alb) response to stress (Alb) cytoplasm (Alb)
Anatomy Link Frequency
liver 4
brain 4
Alb (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 7 99.74 Very High Very High Very High
anesthesia 6 99.64 Very High Very High Very High
agonist 24 98.96 Very High Very High Very High
antagonist 10 98.32 Very High Very High Very High
Central nervous system 8 90.56 High High
imagery 7 87.20 High High
melanocortin 1 receptor 33 83.52 Quite High
pruritus 22 63.64 Quite High
Morphine 2 53.76 Quite High
addiction 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 374 99.20 Very High Very High Very High
Disease Progression 6 98.20 Very High Very High Very High
Biliary Liver Cirrhosis 150 96.76 Very High Very High Very High
Syndrome 29 95.00 High High
Hyperbilirubinemia 1 94.40 High High
Cv Unclassified Under Development 18 92.92 High High
Diabetes Mellitus 62 91.52 High High
Liver Cancer 33 91.28 High High
Hyperinsulinism 21 90.44 High High
Hyperglycemia 12 89.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even when the animal is acclimated to handling, handling or anesthesia can cause marked changes to commonly measured biological parameters such as serum hormone and tissue metabolite levels.
Regulation (changes) of serum hormone associated with anesthesia
1) Confidence 0.43 Published 1990 Journal Fundam Appl Toxicol Section Abstract Doc Link 2197144 Disease Relevance 0.22 Pain Relevance 0.10
Finally, we generated Alb-hßigh3 transgenic mice that overexpress hßigh3 under the control of the Alb enhancer/promoter.
Regulation (control) of Alb associated with targeted disruption
2) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 0.85 Pain Relevance 0
igh3 was produced under control of the albumin promoter (Figure 1D).
Regulation (control) of albumin
3) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2185514 Disease Relevance 1.07 Pain Relevance 0
In contrast, the disappearance from the brain of technetium pertechnetate (a substance also transported out of the brain by a different saturable system), albumin or D-Tyr-MIF-1 (a stereoisomer of Tyr-MIF-1 that was confirmed not to be transported by the carrier system) was not affected by aluminum.
Neg (not) Regulation (affected) of albumin in brain
4) Confidence 0.30 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2894456 Disease Relevance 0 Pain Relevance 0.09
Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin.
Regulation (effect) of albumin in brain associated with enkephalin
5) Confidence 0.18 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2894456 Disease Relevance 0 Pain Relevance 0.18
Furthermore, with this monitoring system, activity of serum SEAP could be affected by ingestion of some AhR agonists and/or antagonists in foods (Amakura et al. 2003a, 2003b), as well as by alterations in the levels of putative, endogenous AhR ligands, including tryptophane photooxidation products, lypoxin A4, indirubin, bilirubin, biliverdin, and an indole derivative (Puga et al. 2005).
Regulation (affected) of serum SEAP associated with antagonist and agonist
6) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.08 Pain Relevance 0.10
However, it must be noted that the detection sensitivity of the established mice is not extremely high; that is, the level of serum SEAP was not altered in response to 0.1 ?
Neg (not) Regulation (altered) of serum SEAP
7) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.09 Pain Relevance 0.09
The change in the urinary albumin/creatinine ratio with combination therapy (?
Regulation (change) of albumin
8) Confidence 0.13 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.72 Pain Relevance 0
Throughout the experiments, wild-type mice administered TCDD did not show alterations in the level of serum SEAP (Figure 2A).
Neg (not) Regulation (alterations) of serum SEAP
9) Confidence 0.13 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.05 Pain Relevance 0.03
For this purpose, we generated lines of transgenic mice expressing high levels of agouti in the liver under the regulatory control of the albumin promoter.
Regulation (control) of albumin promoter in liver associated with targeted disruption
10) Confidence 0.12 Published 2004 Journal Mol Cancer Section Abstract Doc Link PMC443512 Disease Relevance 1.18 Pain Relevance 0.22
alb, albumin promoter; alb-agouti mice, transgenic mice expressing the wild-type agouti cDNA in the liver under the regulatory control of the albumin promoter; ?
Regulation (control) of albumin promoter in liver associated with targeted disruption
11) Confidence 0.12 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.38 Pain Relevance 0.17
To address this question, lines of transgenic mice were generated in which the wild-type agouti cDNA was ectopically expressed only in the liver under the regulatory control of the albumin promoter.
Regulation (control) of albumin promoter in liver associated with targeted disruption
12) Confidence 0.12 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.23 Pain Relevance 0
In time-course studies, we showed that 10 minutes after the injection of radio-iodinated p97, more radioactivity was detected in the brain than after injection of radio-labeled albumin control.
Regulation (control) of albumin in brain
13) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.30 Pain Relevance 0.04
However, after 1 hr, p97 was found to accumulate in the brain while its uptake in all other organs fell to the same level as the albumin control.
Regulation (control) of albumin in brain
14) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.25 Pain Relevance 0.10
Liver synthetic function, i.e.: changes in albumin and prothrombin time (PT) are observed with disease progression.
Regulation (changes) of albumin in Liver associated with disease progression
15) Confidence 0.04 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266722 Disease Relevance 1.77 Pain Relevance 0.08
METHODS: We examined the effect of ethanol ingestion on serum endomorphin (EM)-1 and MEnk levels.
Spec (examined) Regulation (effect) of serum endomorphin
16) Confidence 0.02 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15166656 Disease Relevance 0 Pain Relevance 0

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