INT217630

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gpx1) aging (Gpx1) lipid metabolic process (Gpx1)
cytoplasm (Gpx1) cytosol (Gpx1) cell proliferation (Gpx1)
Anatomy Link Frequency
embryos 4
liver 2
Gpx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 137 97.80 Very High Very High Very High
Aging 2 96.88 Very High Very High Very High
Gestational Diabetes 18 77.80 Quite High
Congenital Anomalies 16 77.04 Quite High
Exencephaly /

Neural Tube Defects

4 76.88 Quite High
Stress 27 50.00 Quite Low
Apoptosis 20 50.00 Quite Low
Disorder Of Lipid Metabolism 2 21.32 Low Low
Parkinson's Disease 2 15.92 Low Low
Body Weight 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of liver glutathione peroxidase (GPx) activity
Negative_regulation (Measurement) of Transcription (activity) of GPx in liver
1) Confidence 0.41 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127222 Disease Relevance 0.18 Pain Relevance 0
In addition, Gpx-1 mRNA levels were more decreased in MDm than in MDn embryos, and Gpx-2 and catalase expression did not differ between the groups (Fig. 2).
Negative_regulation (decreased) of Transcription (levels) of Gpx-1 in embryos
2) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.41 Pain Relevance 0
In addition, in the present study we detected decreased Gpx-1 mRNA levels in MDm embryos and a corresponding reduction of Gpx-1 protein in the cardiac tissues of the MDm embryos, both findings differing from MDn embryos of the same litters, as well as from Gpx-1 estimations in N embryos.
Negative_regulation (decreased) of Transcription (levels) of Gpx-1 in embryos
3) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.39 Pain Relevance 0

General Comments

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