INT217658

Context Info Confidence 0.30 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 1.35 Pain Relevance 0.17

extracellular space (MSTN) growth (MSTN) extracellular region (MSTN) cytoplasm (MSTN)

Anatomy Link Frequency muscle 2 myocytes 1 fat 1 MSTN (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 66 91.68 positron emission tomography 18 88.48 Inflammation 36 63.12 Spinal cord 9 5.00 cytokine 9 5.00 depression 7 5.00 antidepressant 6 5.00 Neurotransmitter 6 5.00 qutenza 6 5.00 Action potential 6 5.00

Disease Link Frequency Relevance Heat Frailty 111 99.92 Disease 9 92.08 Acquired Immune Deficiency Syndrome Or Hiv Infection 24 87.60 Hypoglycemia 3 87.52 Parkinson's Disease 9 68.68 Appetite Loss 13 64.40 INFLAMMATION 36 63.12 Body Weight 24 49.68 Reprotox - General 1 4 45.88 Endometriosis (extended) 5 22.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Among the newer approaches evolving towards treatment of muscle wasting is inhibition of myostatin, which counteracts the myogenic regulatory factors which promote the differentiation and proliferation of myocytes.

Negative_regulation (inhibition) of myostatin in myocytes associated with frailty

1) Confidence 0.30 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.38 Pain Relevance 0

These have had mixed results, and newer approaches, such as myostatin inhibition and selective androgen receptor modulators, are also in the early stages of investigation.

Negative_regulation (inhibition) of myostatin

2) Confidence 0.30 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.21 Pain Relevance 0.17

While there is considerable work which has demonstrated that myostatin suppression may have therapeutic potential for combating muscle wasting, the effect of age on myostatin expression is still under active investigation.

Negative_regulation (suppression) of myostatin in muscle associated with frailty

3) Confidence 0.22 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.17 Pain Relevance 0

In agriculture research, eliminating and/or inhibiting myostatin may serve as an effective way to optimize animal growth leading to larger, leaner, and a more profitable livestock yield.

Negative_regulation (inhibiting) of myostatin

4) Confidence 0.14 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129137 Disease Relevance 0.16 Pain Relevance 0

While these theoretical possibilities may have great promise, research on the role of myostatin inhibition on muscle growth and repair is in the very early stages – particularly in humans.

Negative_regulation (inhibition) of myostatin in muscle

5) Confidence 0.14 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129137 Disease Relevance 0.36 Pain Relevance 0

Cytoseira canariensis has been marketed to increase muscle mass and decrease body fat by inhibiting myostatin, a growth and differentiation factor whose role is to inhibit (not promote) the growth of muscles.

Negative_regulation (inhibiting) of myostatin in fat

6) Confidence 0.06 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129138 Disease Relevance 0.06 Pain Relevance 0

General Comments

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