INT217659

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MSTN) growth (MSTN) extracellular region (MSTN)
cytoplasm (MSTN)
Anatomy Link Frequency
muscle 4
nucleus 2
vastus lateralis 2
body 2
MSTN (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 68 5.00 Very Low Very Low Very Low
Inflammation 40 5.00 Very Low Very Low Very Low
positron emission tomography 18 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
Spinal cord 9 5.00 Very Low Very Low Very Low
qutenza 6 5.00 Very Low Very Low Very Low
Action potential 6 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
antidepressant 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 107 99.88 Very High Very High Very High
Appetite Loss 7 86.80 High High
Body Weight 8 72.08 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 66.00 Quite High
Rheumatoid Arthritis 16 61.92 Quite High
Increased Venous Pressure Under Development 2 58.32 Quite High
Aging 57 50.64 Quite High
Hypoxia 2 42.72 Quite Low
Congenital Anomalies 3 16.24 Low Low
Apoptosis 9 15.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, while myostatin is an important target in combating muscle wasting, the role of age-related changes in myostatin expression is still a controversial subject.



Regulation (changes) of Gene_expression (expression) of myostatin in muscle associated with frailty
1) Confidence 0.31 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.26 Pain Relevance 0
With respect to studies in human models of muscle wasting, there is similar variance in findings, with one cross-sectional study reporting no change in myostatin expression in the vastus lateralis muscle between young and older men [56], while a similar study in women found a 56% increase in myostatin expression in the vastus lateralis [57].
Neg (no) Regulation (change) of Gene_expression (expression) of myostatin in vastus lateralis associated with frailty
2) Confidence 0.31 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.26 Pain Relevance 0
While there is considerable work which has demonstrated that myostatin suppression may have therapeutic potential for combating muscle wasting, the effect of age on myostatin expression is still under active investigation.
Regulation (effect) of Gene_expression (expression) of myostatin in muscle associated with frailty
3) Confidence 0.14 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.23 Pain Relevance 0
An intriguing new finding was the marked (and so far as we can tell previously unreported) changes in the expression of myostatin and myoD with feeding, which are consistent with an acute nutritional control at the level of the nucleus of processes regulating muscle mass [55].
Regulation (changes) of Gene_expression (expression) of myostatin in nucleus
4) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.06 Pain Relevance 0
Nevertheless, there was no apparent sex difference in these responses, which makes it unlikely that the feeding-induced changes in myostatin and myoD expression contributed to the blunted increase of MPS to feeding in women.
Regulation (changes) of Gene_expression (expression) of myostatin
5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.11 Pain Relevance 0
However, Willoughby [44] reported that 1,200 milligrams/day of Cystoseira canariensis supplementation during 12 weeks of resistance training had no effect on serum myostatin levels, not did it have any effect on muscle mass, muscle strength, or body fat.
Neg (no) Regulation (effect) of Gene_expression (levels) of myostatin in body
6) Confidence 0.02 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129138 Disease Relevance 0.22 Pain Relevance 0

General Comments

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