INT217659

Context Info Confidence 0.31 First Reported 2006 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 1.15 Pain Relevance 0

extracellular space (MSTN) growth (MSTN) extracellular region (MSTN) cytoplasm (MSTN)

Anatomy Link Frequency muscle 4 nucleus 2 vastus lateralis 2 body 2 MSTN (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 68 5.00 Inflammation 40 5.00 positron emission tomography 18 5.00 cytokine 11 5.00 Spinal cord 9 5.00 qutenza 6 5.00 Action potential 6 5.00 depression 5 5.00 antidepressant 4 5.00 Neurotransmitter 4 5.00

Disease Link Frequency Relevance Heat Frailty 107 99.88 Appetite Loss 7 86.80 Body Weight 8 72.08 Acquired Immune Deficiency Syndrome Or Hiv Infection 2 66.00 Rheumatoid Arthritis 16 61.92 Increased Venous Pressure Under Development 2 58.32 Aging 57 50.64 Hypoxia 2 42.72 Congenital Anomalies 3 16.24 Apoptosis 9 15.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, while myostatin is an important target in combating muscle wasting, the role of age-related changes in myostatin expression is still a controversial subject.

Regulation (changes) of Gene_expression (expression) of myostatin in muscle associated with frailty

1) Confidence 0.31 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.26 Pain Relevance 0

With respect to studies in human models of muscle wasting, there is similar variance in findings, with one cross-sectional study reporting no change in myostatin expression in the vastus lateralis muscle between young and older men [56], while a similar study in women found a 56% increase in myostatin expression in the vastus lateralis [57].

Neg (no) Regulation (change) of Gene_expression (expression) of myostatin in vastus lateralis associated with frailty

2) Confidence 0.31 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.26 Pain Relevance 0

While there is considerable work which has demonstrated that myostatin suppression may have therapeutic potential for combating muscle wasting, the effect of age on myostatin expression is still under active investigation.

Regulation (effect) of Gene_expression (expression) of myostatin in muscle associated with frailty

3) Confidence 0.14 Published 2009 Journal Osteoporos Int Section Body Doc Link PMC2832869 Disease Relevance 0.23 Pain Relevance 0

An intriguing new finding was the marked (and so far as we can tell previously unreported) changes in the expression of myostatin and myoD with feeding, which are consistent with an acute nutritional control at the level of the nucleus of processes regulating muscle mass [55].

Regulation (changes) of Gene_expression (expression) of myostatin in nucleus

4) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.06 Pain Relevance 0

Nevertheless, there was no apparent sex difference in these responses, which makes it unlikely that the feeding-induced changes in myostatin and myoD expression contributed to the blunted increase of MPS to feeding in women.

Regulation (changes) of Gene_expression (expression) of myostatin

5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.11 Pain Relevance 0

However, Willoughby [44] reported that 1,200 milligrams/day of Cystoseira canariensis supplementation during 12 weeks of resistance training had no effect on serum myostatin levels, not did it have any effect on muscle mass, muscle strength, or body fat.

Neg (no) Regulation (effect) of Gene_expression (levels) of myostatin in body

6) Confidence 0.02 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129138 Disease Relevance 0.22 Pain Relevance 0

General Comments

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