INT217683

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.28
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
stem cell 3
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 79 94.72 High High
Pain 9 80.32 Quite High
depression 2 78.08 Quite High
Serotonin 6 33.80 Quite Low
Neuropeptide 13 32.32 Quite Low
Cholecystokinin 5 19.36 Low Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
behavioral therapy 9 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 387 100.00 Very High Very High Very High
Cancer 340 100.00 Very High Very High Very High
Low Back Pain 79 94.72 High High
Nicotine Addiction 97 92.76 High High
Carcinoma 12 80.88 Quite High
Pain 9 80.32 Quite High
Anxiety Disorder 6 78.72 Quite High
Depression 2 78.08 Quite High
Overnutrition 2 77.84 Quite High
Squamous Cell Carcinoma 16 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, our results suggest existence of distinct subsets of cancer cells which express CTIP2 and underscore the use of CTIP2 and BMI1 co-labeling to identify tumor initiating cancer stem cells (CSC).


Localization (use) of BMI1 in stem cells associated with cancer
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.58 Pain Relevance 0
In well and moderate to poorly differentiated tumors, majority of the BMI1 expressing cells showed strong nuclear co-localization of CTIP2 and BMI1 proteins (CTIP2+/BMI1+) (Fig. 2C & D).
Localization (co-localization) of BMI1 associated with cancer
2) Confidence 0.64 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.63 Pain Relevance 0
Nuclear co-localization of CTIP2 protein and cancer stem cell (CSC) marker BMI1 was observed in most, if not all of the cells expressing BMI1 in moderately and poorly differentiated tumors.


Localization (localization) of BMI1 in stem cell associated with cancer
3) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671404 Disease Relevance 0.84 Pain Relevance 0
Nuclear co-localization of CTIP2 protein and cancer stem cell (CSC) marker BMI1 was observed in most, if not all of the cells expressing BMI1 in moderately and poorly differentiated tumors.


Localization (-) of BMI1 in stem cell associated with cancer
4) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2671404 Disease Relevance 0.84 Pain Relevance 0
Measurement of HRQoL and BMI
Localization (Measurement) of BMI associated with obesity
5) Confidence 0.09 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2788145 Disease Relevance 0.34 Pain Relevance 0.12
In multivariate analyses, sex (P < 0.0001) and age (P < 0.0001) were found to be significant effect modifiers, while BMI (P < 0.001) and education (P < 0.0001) were significant confounders.
Localization (education) of BMI associated with obesity
6) Confidence 0.08 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004651 Disease Relevance 2.18 Pain Relevance 0.75
Iacobellis et al. [75] reported that TSH and BMI were positively related and TSH has been found to be correlated with leptin adjusted for BMI.
Localization (related) of BMI associated with obesity
7) Confidence 0.00 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.88 Pain Relevance 0

General Comments

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