INT217684

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LIPG) extracellular space (LIPG) extracellular region (LIPG)
lipid metabolic process (LIPG)
Anatomy Link Frequency
plasma 1
fat 1
LIPG (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 8 66.48 Quite High
Bioavailability 18 60.92 Quite High
Neuropeptide 16 30.60 Quite Low
cytokine 11 22.64 Low Low
medulla 4 14.24 Low Low
antagonist 21 5.00 Very Low Very Low Very Low
agonist 17 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
behavioral therapy 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 285 99.12 Very High Very High Very High
Repression 6 96.88 Very High Very High Very High
Disorder Of Lipid Metabolism 10 90.88 High High
Hypertrophy 8 86.24 High High
Necrosis 4 84.88 Quite High
Cancer 13 84.52 Quite High
Dyslipidemia /

Combined Dyslipidemia

4 81.64 Quite High
Hyperlipidemia 5 80.76 Quite High
Congenital Anomalies 5 78.52 Quite High
Renal Failure 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fenofibrate increases the lipolyses and the elimination of TH-rich particles from the plasma by activating the lipoprotein lipase and reducing the production of apoprotein C-III, which is an inhibitor of the lipoprotein lipase activity.
Positive_regulation (activating) of lipoprotein lipase in plasma
1) Confidence 0.04 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626933 Disease Relevance 0.47 Pain Relevance 0.03
Testosterone reduces lipoprotein lipase activity and increases lipolysis in males, but in females these effects are counteracted by estrogen [71].
Positive_regulation (increases) of lipoprotein lipase
2) Confidence 0.04 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.91 Pain Relevance 0.09
Relevant mechanisms embrace repression of insulin-sensitizing genes, such as adiponectin, and induction of adipocyte leptin and peroxisome-proliferating activator receptor- (PPAR-) gamma genes; stimulation of endothelial lipoprotein lipase, adipocyte fatty acid synthase, acetyl CoA carboxylase, and fat-cell glucose uptake; and inhibition of fat oxidation via rate-limiting carnitine-palmitoyl transferase [167, 171, 172, 191, 554, 555].
Positive_regulation (stimulation) of endothelial lipoprotein lipase in fat associated with repression
3) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.43 Pain Relevance 0

General Comments

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