INT217685

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 6.01
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (BMI1) nucleus (BMI1) cytoplasm (BMI1)
Anatomy Link Frequency
body 2
fat 1
BMI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 79 100.00 Very High Very High Very High
depression 53 97.92 Very High Very High Very High
fluoxetine 1 94.60 High High
antidepressant 25 88.54 High High
cytokine 24 69.60 Quite High
behavioral therapy 26 61.84 Quite High
Neuropeptide 39 5.00 Very Low Very Low Very Low
Osteoarthritis 33 5.00 Very Low Very Low Very Low
Serotonin 19 5.00 Very Low Very Low Very Low
Cholecystokinin 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 894 100.00 Very High Very High Very High
Nicotine Addiction 91 100.00 Very High Very High Very High
Low Back Pain 79 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 23 99.92 Very High Very High Very High
Body Weight 46 99.80 Very High Very High Very High
Weight Loss 327 99.58 Very High Very High Very High
Depression 67 97.92 Very High Very High Very High
Overweight 115 92.28 High High
Diabetes Mellitus 166 90.00 High High
Apnoea 202 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with antidepressants have shown variable effects on metabolic control.13,14,24–26 In a study with sertraline, HbA1c levels were reduced during treatment but did not differ between the sertraline and placebo groups.13 In another study no significant reduction in HbA1c levels was observed in patients treated with fluoxetine or paroxetine although depressive symptoms were significantly improved.14,24 Similarly, treatment with escitalopram resulted in a significant reduction of depression ratings but only a modest, non-significant reduction in fBG levels and HbA1c levels.25 With bupropion, BMI and HbA1c levels decreased significantly over an acute treatment phase with the reduction of depression severity associated with lower HbA1c levels.26
Negative_regulation (decreased) of BMI associated with antidepressant, depression and fluoxetine
1) Confidence 0.18 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695229 Disease Relevance 1.16 Pain Relevance 0.50
The prevalence of LBP according to smoking status, age, sex, BMI, physical activity and level of education was calculated.
Negative_regulation (prevalence) of BMI associated with nicotine addiction, obesity and backache
2) Confidence 0.05 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004651 Disease Relevance 1.13 Pain Relevance 0.29
When BMI was replaced by waist circumference in the regression analysis, the LowSaO2 maintained an independent association with TNF-?
Negative_regulation (replaced) of BMI
3) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.24 Pain Relevance 0.03
Results were similar when BMI was replaced by waist circumference in the regression model (P < 0.001).


Negative_regulation (replaced) of BMI
4) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.29 Pain Relevance 0
In a retrospective, nonrandomized study of the effects of a low-GI diet (n = 64) compared with a conventional reduced-fat diet (n = 43) in the management of pediatric obesity, greater decreases in BMI and body weight were seen in the low-GI group, even after adjustment for age, sex, ethnicity, baseline BMI, and baseline weight [150].


Negative_regulation (decreases) of BMI in body associated with body weight and obesity
5) Confidence 0.01 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 1.11 Pain Relevance 0
Subjects experienced significant decreases in weight, percentage body fat, BMI, total cholesterol, LDL-C, total caloric intake, and the percentage of energy intake from dietary fat as well as a significant increase in VO2max (P < 0.05) at 3 months.
Negative_regulation (decreases) of BMI in fat associated with obesity and disorder of lipid metabolism
6) Confidence 0.01 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 1.31 Pain Relevance 0
In these subjects, the mean (± SD) body weight decreased 10.3% ± 5.9% (P < 0.001) from baseline to 6 months (body weight reduction of 9.0 ± 5.3 kg and BMI reduction of 3.2 ± 1.9 kg/m (2)).
Negative_regulation (reduction) of BMI in body associated with weight loss, body weight and obesity
7) Confidence 0.01 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.76 Pain Relevance 0

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