INT217691

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 24
Total Number 45
Disease Relevance 29.84
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LIPE) extracellular space (LIPE) small molecule metabolic process (LIPE)
lipid particle (LIPE) plasma membrane (LIPE) lipid metabolic process (LIPE)
Anatomy Link Frequency
muscle 12
adipose tissues 6
fat 4
skeletal muscle 3
adipocytes 2
LIPE (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 10 98.48 Very High Very High Very High
Catecholamine 204 96.24 Very High Very High Very High
Central nervous system 49 96.10 Very High Very High Very High
agonist 143 95.28 Very High Very High Very High
addiction 9 87.40 High High
noradrenaline 283 85.04 High High
tolerance 1 67.92 Quite High
anesthesia 80 54.08 Quite High
alcohol 20 5.00 Very Low Very Low Very Low
cytokine 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 5793 100.00 Very High Very High Very High
Natriuresis 1 99.32 Very High Very High Very High
Congenital Anomalies 47 92.92 High High
Scoliosis 942 87.68 High High
Hyperinsulinism 20 85.92 High High
Diabetes Mellitus 107 74.44 Quite High
Weight Loss 133 65.60 Quite High
Insulin Resistance 74 63.32 Quite High
Body Weight 50 52.24 Quite High
Sprains And Strains 20 41.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some differences in HSL gene expression between fat depots have been previously reported [21,26,27].
Gene_expression (expression) of HSL gene in fat
1) Confidence 0.70 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.55 Pain Relevance 0.03
Our data suggest that there was no depot-specific difference in HSL protein expression in our cohort.
Gene_expression (expression) of HSL protein
2) Confidence 0.70 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.65 Pain Relevance 0.03
Perilipin and HSL expressions in obese women
Gene_expression (expressions) of HSL associated with obesity
3) Confidence 0.70 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.85 Pain Relevance 0
Perilipin and HSL mRNA expression
Gene_expression (expression) of HSL mRNA
4) Confidence 0.70 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.10 Pain Relevance 0.27
In the present study, regional differences of perilipin A and HSL expressions were examined in lean and obese women.
Gene_expression (expressions) of HSL associated with obesity
5) Confidence 0.70 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.81 Pain Relevance 0.07
Depot-specific differences in HSL expression
Gene_expression (expression) of HSL
6) Confidence 0.61 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.70 Pain Relevance 0.06
Despite higher HSL mRNA levels in SC versus OM adipose tissues, we did not find any regional difference in HSL protein content in both lean and obese women and in HSL activity in the obese women (lean women were not analyzed for HSL activity).
Gene_expression (content) of HSL protein in adipose tissues associated with obesity
7) Confidence 0.61 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.64 Pain Relevance 0.06
Despite higher HSL mRNA levels in SC versus OM adipose tissues, we did not find any regional difference in HSL protein content in both lean and obese women and in HSL activity in the obese women (lean women were not analyzed for HSL activity).
Gene_expression (levels) of HSL mRNA in adipose tissues associated with obesity
8) Confidence 0.61 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.71 Pain Relevance 0.06
Despite higher HSL mRNA levels in SC versus OM adipose tissues, we did not find any regional difference in HSL protein content in both lean and obese women and in HSL activity in the obese women (lean women were not analyzed for HSL activity).
Gene_expression (activity) of HSL in adipose tissues associated with obesity
9) Confidence 0.61 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.58 Pain Relevance 0.03
In both depots, HSL mRNA abundance in the obese women were 300% higher than in the lean women (p < 0.05).
Gene_expression (abundance) of HSL mRNA associated with obesity
10) Confidence 0.61 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 1.65 Pain Relevance 0
Despite the crucial role of the adipose tissue heterogeneity, few studies only attempt to compare expression of HSL and perilipin in different fat depots.
Gene_expression (expression) of HSL in fat associated with obesity
11) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 1.01 Pain Relevance 0.04
The present report aimed at examining whether HSL and perilipin A were differently expressed in abdominal SC and OM adipose tissues of women and if these expressions and regional differences were modified in obese subjects.


Gene_expression (expressed) of HSL in adipose tissues associated with obesity
12) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 1.10 Pain Relevance 0.10
Regarding HSL expression, a decrease is reported in SC depot of obese subjects versus lean subjects [4].
Gene_expression (expression) of HSL associated with obesity
13) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 1.15 Pain Relevance 0.05
The present study aimed at comparing expression and subcellular distribution of perilipin and hormone-sensitive lipase in two abdominal adipose tissues of lean and obese women.
Gene_expression (expression) of hormone-sensitive lipase in adipose tissues associated with obesity
14) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2804660 Disease Relevance 0.47 Pain Relevance 0.03
A more distal defect in catecholamine signal transduction at the level of hormone-sensitive lipase (HSL, the rate-limiting enzyme for hydrolysis of stored TAGs) is observed in SC fat of obese women and is linked to decreased expression and activity of HSL [4].
Gene_expression (expression) of HSL in fat associated with catecholamine and obesity
15) Confidence 0.54 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.75 Pain Relevance 0.09
The HSL distribution was comparable in the lean and the obese subjects whatever the fat depot, except in lean and obese FC fractions which displayed an HSL content in OM depot twice as high as in SC fat tissue.


Gene_expression (distribution) of HSL in fat associated with obesity
16) Confidence 0.53 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 1.03 Pain Relevance 0.03
Depot difference in the HSL distribution could therefore influence HSL regulation and modulate TAG accumulation.
Gene_expression (distribution) of HSL
17) Confidence 0.53 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.51 Pain Relevance 0.04
In both depots, HSL and perilipin amounts were lower in the obese than in the lean subjects (P < 0.05), this difference being particularly important for perilipin.
Gene_expression (amounts) of HSL associated with obesity
18) Confidence 0.53 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2804660 Disease Relevance 0.93 Pain Relevance 0
To obtain more information on the underlying mechanism at the molecular level, we measured skeletal muscle HSL protein expression and serine phosphorylation on Ser563, Ser565, and Ser659.
Gene_expression (expression) of HSL protein in skeletal muscle
19) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.37 Pain Relevance 0.09
Total HSL protein expression and serine phosphorylation in the vastus lateralis muscle.
Gene_expression (expression) of HSL protein in vastus lateralis
20) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2453623 Disease Relevance 0.90 Pain Relevance 0

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