INT217717

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.98
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
B-cell 2
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 1 40.96 Quite Low
opiate 9 5.00 Very Low Very Low Very Low
Opioid 9 5.00 Very Low Very Low Very Low
positron emission tomography 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 13 100.00 Very High Very High Very High
Lymphatic System Cancer 68 99.68 Very High Very High Very High
Follicular Lymphoma 13 63.48 Quite High
Toxicity 16 59.60 Quite High
Acute Myeloid Leukemia 13 59.00 Quite High
Thrombocytopenia 8 55.92 Quite High
Neutropenia 5 55.08 Quite High
Hypertrophy 15 47.76 Quite Low
Fatigue 6 44.68 Quite Low
Diffuse Large B-cell Lymphoma 7 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, residual RTX remains in patientsÂ’ serum for three to six months after treatment and could potentially block CD20 binding sites.46 Preclinical studies using human lymphoma cell lines, patient-derived specimens, and mouse xenograft models have shown that prior RTX therapy reduces CD20 binding, tumor-specific localization, and tumor control for 131I-TST.46 Despite this preclinical data, 131I-TST has been shown to be clinically effective in RTX-refractory relapsed low grade B-cell NHL as discussed previously.31 Future clinical studies should help determine whether inclusion of RTX in induction chemotherapy regimens abrogates the incremental therapeutic gain of consolidation 131I-TST found in the studies listed in Table 4.


Positive_regulation (reduces) of Protein_catabolism (grade) of CD20 in B-cell associated with lymphatic system cancer and cancer
1) Confidence 0.16 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.98 Pain Relevance 0
Several proteins expressed at higher levels in younger donors support metabolic activity, protect against oxidative damage, or mediate protein folding or degradation.


Positive_regulation (mediate) of Protein_catabolism (degradation) of protein
2) Confidence 0.03 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2565687 Disease Relevance 0 Pain Relevance 0
While protein synthesis is elevated up to 48 hours following an exercise session, protein degradation is also increased; resulting in a negative protein balance if additional nutrients are not supplied [7].
Positive_regulation (increased) of Protein_catabolism (degradation) of protein
3) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
It is generally thought that insulin enhances protein balance through hindering protein degradation [40,92], which was supported by this study.
Positive_regulation (supported) of Protein_catabolism (degradation) of protein
4) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
However, protein degradation is markedly increased during exercise and results in a net negative protein balance [60].
Positive_regulation (increased) of Protein_catabolism (degradation) of protein
5) Confidence 0.00 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox