INT217719

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 3.93
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (IDS)
Anatomy Link Frequency
muscle 2
chest 2
blood 1
leg 1
IDS (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 215 99.26 Very High Very High Very High
imagery 110 96.56 Very High Very High Very High
depression 7 36.60 Quite Low
tolerance 15 32.32 Quite Low
Inflammation 16 5.00 Very Low Very Low Very Low
adenocard 15 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
opiate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 175 100.00 Very High Very High Very High
Infarction 60 100.00 Very High Very High Very High
Syndrome 30 99.46 Very High Very High Very High
Angina 140 99.26 Very High Very High Very High
Myocardial Infarction 120 98.80 Very High Very High Very High
Aging 50 97.76 Very High Very High Very High
Acute Coronary Syndrome 75 97.24 Very High Very High Very High
Cardiovascular Disease 45 95.12 Very High Very High Very High
Cv General 3 Under Development 80 94.56 High High
Bacterial Respiratory Disease 6 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar programs could be implemented in MTH for cost effective use of IDs/IVFs.
Positive_regulation (implemented) of IDs
1) Confidence 0.40 Published 2009 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2687907 Disease Relevance 0.09 Pain Relevance 0
MPS with vasodilator stress can be performed safely as early as 3 days after infarction, before the majority of recurrent clinical events occur, and can be used to guide early discharge [245].
Positive_regulation (used) of MPS associated with stress and infarction
2) Confidence 0.27 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.80 Pain Relevance 0.05
The EMPIRE study compared patients presenting with stable chest pain syndromes to centres that routinely use MPS and those that do not in each of four European countries [252].
Positive_regulation (use) of MPS in chest associated with angina and syndrome
3) Confidence 0.27 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.62 Pain Relevance 0.26
MPS with vasodilator stress can be performed safely as early as 3 days after infarction, before the majority of recurrent clinical events occur, and can be used to guide early discharge [245].
Positive_regulation (performed) of MPS associated with stress and infarction
4) Confidence 0.27 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.77 Pain Relevance 0.04
However, some data have been derived from decision analytical models and these have demonstrated the cost-effectiveness of MPS both in patients presenting with stable chest pain syndromes [254] and in pre-operative risk assessment [255].
Positive_regulation (effectiveness) of MPS in chest associated with angina and syndrome
5) Confidence 0.27 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.34 Pain Relevance 0.18
European guidelines are that MPS should be performed for risk stratification after NSTEMI in patients who cannot exercise, in those with unhelpful exercise ECG tests and in women [275].
Positive_regulation (performed) of MPS
6) Confidence 0.27 Published 2003 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2562441 Disease Relevance 0.65 Pain Relevance 0.09
Nevertheless, there was no apparent sex difference in these responses, which makes it unlikely that the feeding-induced changes in myostatin and myoD expression contributed to the blunted increase of MPS to feeding in women.
Positive_regulation (increase) of MPS
7) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.12 Pain Relevance 0
The differences in the anabolic response to feeding between the sexes, with men showing a significant increase and women no significant increase in MPS, was probably partially mediated by a lack of stimulation by feeding of protein translation initiation in female muscle, given that the feeding increased the phosphorylation of muscle eIF4ESer209 and eIF4E-BP1Thr37/46 in men but not in women.
Neg (no) Positive_regulation (increase) of MPS in muscle
8) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.08 Pain Relevance 0
The greater basal rate of mixed MPS in older women was probably mediated by a combination of a greater capacity for protein synthesis combined with a relatively more active translational process at the elongation stage of protein synthesis because first, there was the trend for a ?
Positive_regulation (mediated) of MPS
9) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.27 Pain Relevance 0
Accordingly, feeding increased MPS in men (P<0.01) but not in women.
Neg (not) Positive_regulation (increased) of MPS
10) Confidence 0.04 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2267222 Disease Relevance 0.07 Pain Relevance 0
15%, possibly too small to exert a noticeable effect on the rate of MPS as MPS only increases by 50% with a doubling of leucine concentration [46].
Positive_regulation (increases) of MPS
11) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2267222 Disease Relevance 0.06 Pain Relevance 0
The stimulation of muscle protein synthesis (MPS) observed on consumption of mixed food appears to be mainly a result of the increased availability of amino acids; thus amino acids alone appear to be able to stimulate human MPS (3, 11, 30) in a dose-response manner (6, 8) and at fixed postabsorptive concentrations of plasma insulin (8).
Positive_regulation (stimulate) of MPS in muscle
12) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
The protocol (Fig. 1) was designed to allow the measurement of MPS (by incorporation of [1-13C]leucine into quadriceps protein), LPS as rate of disappearance of phenylalanine (i.e., LPB-leg balance), and LPB as rate of dilution of [2H5]phenylalanine (27) under graded steady-state serum insulin concentrations, but all with increased availability of blood amino acids resulting from infusion of amino acids at a fixed high rate of 18 g/h.
Positive_regulation (allow) of MPS in leg
13) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.07 Pain Relevance 0
Thus the current view that increases in MPS follow from proportionate alterations in the activity of signaling molecules (indicated by alteration of phosphorylation status after manipulation of insulin and amino acid availability) may be an oversimplification; it is certainly not supported by the present results.
Positive_regulation (increases) of MPS
14) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Others report a stimulation of MPS with close arterial infusion (4, 13, 26), and the difference has been suggested to be due to the preservation of increases in intramuscular amino acid availability (13, 26).
Positive_regulation (stimulation) of MPS
15) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Certainly, when amino acid delivery is increased together with insulin, there is no difficulty in observing a stimulation of MPS measured by incorporation of tracer amino acids into protein or by their disappearance from arterial blood (1, 16).
Positive_regulation (stimulation) of MPS in blood
16) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Some workers have reported increases of MPS and LPS with close arterial insulin contraction without making additional amino acids available (4, 13).
Positive_regulation (increases) of MPS
17) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
However this is at odds with evidence which demonstrates that acute increases in skeletal muscular protein synthesis (MPS) are additive to normal MPS balance, and that there does not appear to be compensation at night [40].
Positive_regulation (increases) of MPS
18) Confidence 0.01 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0
A number of studies provide support that MPS is triggered by an increase in the concentration of EAAs [62].
Positive_regulation (triggered) of MPS
19) Confidence 0.01 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129150 Disease Relevance 0 Pain Relevance 0

General Comments

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