INT217730

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.86
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 3 25.92 Quite Low
headache 1 22.96 Low Low
Neurotransmitter 2 19.20 Low Low
Glutamate 4 17.04 Low Low
Spinal cord 1 15.72 Low Low
Inflammation 7 10.32 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 29 96.80 Very High Very High Very High
Breast Cancer 31 94.72 High High
Obesity 7 92.00 High High
Hyperglycemia 2 90.80 High High
Precocious Puberty 4 72.76 Quite High
Mucositis 1 70.92 Quite High
Diarrhoea 3 70.12 Quite High
Hypogonadotropic Hypogonadism 3 63.08 Quite High
Apoptosis 1 33.80 Quite Low
Toxicity 2 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro data suggest that mTOR inhibition can lead to a paradoxical increase in Akt activation, via a release of negative feedback on upstream signaling through insulin-like growth factor-1 receptor (IGF1R) [53], or direct activation by the rapamycin-insensitive mTOR-rictor complex [54].
Positive_regulation (increase) of Localization (release) of mTOR
1) Confidence 0.33 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.63 Pain Relevance 0
Most recently it was shown that central activation of mammalian target of rapamycin (mTOR), a serine/threonine kinase that operates as sensor of cellular energy status, stimulated LH secretion in pubertal female rats via modulation of hypothalamic KiSS-1, whereas mTOR blockade by rapamycin inhibited gonadotropic axis suggesting that central mTOR signaling has a role in the control of puberty onset and gonadotropin secretion [19].
Positive_regulation (activation) of Localization (target) of mTOR
2) Confidence 0.30 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.23 Pain Relevance 0
There is evidence that the action of signaling molecules such as PKB, mammalian target of rapamycin (mTOR), p70 S6 kinase (p70S6k), and 4E-binding protein-1 (4E-BP1), as in rats (17, 19), is involved in the modulation of human MPS since these are also activated after increased amino acid provision (8, 12, 12, 20, 21).
Positive_regulation (increased) of Localization (target) of mTOR
3) Confidence 0.23 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
When BCAA are administered during and after resistance exercise, phosphorylation of the mammalian target of rapamycin (mTOR) leads to a sequence of (anabolic) enzymatic activations that are not seen to equal extent when BCAA are withheld [23].
Positive_regulation (When) of Localization (target) of mTOR
4) Confidence 0.21 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129153 Disease Relevance 0 Pain Relevance 0

General Comments

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