INT217731

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 10.88 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
lidocaine 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 43 97.84 Very High Very High Very High
Hyperinsulinism 15 83.36 Quite High
Overnutrition 43 81.52 Quite High
INFLAMMATION 10 10.88 Low Low
Injury 18 5.00 Very Low Very Low Very Low
Diabetes Mellitus 16 5.00 Very Low Very Low Very Low
Stress 15 5.00 Very Low Very Low Very Low
Weight Gain 9 5.00 Very Low Very Low Very Low
Obesity 8 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, both overfeeding diets induced significant increases in phosphorylation of mTOR and S6K1, yet only HF overfeeding was associated with increased serine phosphorylation of IRS-1.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.40 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.23 Pain Relevance 0
The phosphorylation of PKB Ser473 and p70S6k Thr389 increased concomitantly with insulin, but whereas raising insulin to 30 mU/l increased the phosphorylation of mTOR Ser2448, 4E-BP1 Thr37/46, or GSK3?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of mTOR
2) Confidence 0.32 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Abstract Doc Link PMC2536736 Disease Relevance 0.08 Pain Relevance 0
However, there was a significant increase in phosphorylated mTOR resulting in increased phosphorylation of S6K1 following both overfeeding diets (Figure 4).


Positive_regulation (increase) of Phosphorylation (phosphorylated) of mTOR
3) Confidence 0.27 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0 Pain Relevance 0
In this study, both overfeeding diets induced significant increases in phosphorylation of mTOR and S6K1, yet only HF overfeeding was associated with increased serine phosphorylation of IRS-1.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of mTOR
4) Confidence 0.27 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.23 Pain Relevance 0
When BCAA are administered during and after resistance exercise, phosphorylation of the mammalian target of rapamycin (mTOR) leads to a sequence of (anabolic) enzymatic activations that are not seen to equal extent when BCAA are withheld [23].
Positive_regulation (leads) of Phosphorylation (phosphorylation) of mTOR
5) Confidence 0.21 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129153 Disease Relevance 0 Pain Relevance 0

General Comments

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