INT217778

Context Info Confidence 0.09 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.19 Pain Relevance 0

cytosol (MAP3K3, RASGRP1) cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) lipid binding (RASGRP1)

MAP3K3 (Homo sapiens) RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 1 5.00

Disease Link Frequency Relevance Heat Colon Cancer 21 80.88 Cancer 39 59.92 Apoptosis 2 23.76 Solid Tumor 1 9.52 Chronic Lymphoid Leukemia 2 8.28 Glioblastoma 1 6.80 Disease 3 5.00 Repression 2 5.00 Colorectal Cancer 2 5.00 Adenocarcinoma 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The hsa-miR-200c is strongly associated with overall patient survival (Figure 2). hsa-miR-200c can potentially regulate over 200 target genes including MAPKKK3, eIF-4E, RAS homologs, RNA polymerase II, and cyclin L1 based on bioinformatics analysis (John et al. 2004).

MAPKKK3 Regulation (regulate) of Gene_expression (homologs) of RAS

1) Confidence 0.09 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.19 Pain Relevance 0

General Comments

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