INT217804

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 19.95
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
Anatomy Link Frequency
central nervous system 2
blood 1
colon 1
lung 1
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 112 99.52 Very High Very High Very High
Central nervous system 17 99.40 Very High Very High Very High
Pain 17 90.00 High High
Chronic pancreatitis 34 76.48 Quite High
Bile 17 69.76 Quite High
cytokine 24 22.72 Low Low
Inflammation 26 5.00 Very Low Very Low Very Low
Spinal cord 17 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2918 99.84 Very High Very High Very High
Autoimmune Disease 12 99.84 Very High Very High Very High
Glioblastoma 86 99.74 Very High Very High Very High
Rheumatoid Arthritis 112 99.52 Very High Very High Very High
Pancreatic Cancer 238 99.46 Very High Very High Very High
Lung Cancer 153 98.88 Very High Very High Very High
Prostate Cancer 340 98.68 Very High Very High Very High
Leukemia 170 98.04 Very High Very High Very High
Viral Infection 2 96.76 Very High Very High Very High
Colon Cancer 89 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of miRNAs were discovered to be deregulated due to the loss of the p53 tumor suppressor in colon cancer cell lines.
Negative_regulation (number) of miRNAs in colon associated with cancer and colon cancer
1) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.70 Pain Relevance 0
For example, in brain (central nervous system and glioblastoma) 94% of the miRNAs (79/84) are downregulated (P = 7.106 × 10-16, Fisher's exact test), and in hematogic, all the miRNAs (32/32) are downregulated (P = 1.642 × 10-8, Fisher's exact test); on the other hand 91.3% of the miRNAs (42/46) are upregulated in pancreatic cancer (P = 6.639 × 10-13, Fisher's exact test) and all the miRNAs (9/9) are upregulated in lymphoma (P = 4.228 × 10-4, Fisher's exact test).
Negative_regulation (downregulated) of miRNAs in central nervous system associated with lymphatic system cancer, glioblastoma, pancreatic cancer and central nervous system
2) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.92 Pain Relevance 0.05
In this network model several cancer types have been identified where almost all the miRNAs are either upregulated or downregulated.
Negative_regulation (downregulated) of miRNAs associated with cancer
3) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.92 Pain Relevance 0
Rest of all the up and downregulated miRNAs from all the cancer types (except the one used in experimental data set) are considered as background data set.
Negative_regulation (downregulated) of miRNAs associated with cancer
4) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.49 Pain Relevance 0
In our present study we found that, 46 miRNAs are dysregulated in pancreatic cancer among which a significant number of miRNAs are overexpressed (P = 6.639 × 10-13, for details see Table 1) showing that miRNAs tend to be upregulated in pancreatic tumor tissue.
Negative_regulation (number) of miRNAs associated with pancreatic cancer
5) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.65 Pain Relevance 0.08
Limited work has been done towards revealing the fact that a number of miRNAs can control commonly altered regulatory pathways.
Negative_regulation (number) of miRNAs
6) Confidence 0.01 Published 2010 Journal Silenc Section Abstract Doc Link PMC2835996 Disease Relevance 0.89 Pain Relevance 0
Limited work has been done towards revealing the fact that a number of miRNAs can control commonly altered regulatory pathways.
Negative_regulation (number) of miRNAs
7) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.15 Pain Relevance 0
In the network, a number of miRNAs are found that are associated with ?
Negative_regulation (number) of miRNAs
8) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.90 Pain Relevance 0.03
Earlier it was believed that miRNAs are globally downregulated in tumor tissues [18].
Negative_regulation (downregulated) of miRNAs associated with cancer
9) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.06 Pain Relevance 0.03
In each module a number of miRNAs are found that are dysregulated in several cancer types.
Negative_regulation (number) of miRNAs associated with cancer
10) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.51 Pain Relevance 0
A number of cancer types have been identified where a significant number of miRNAs are either upregulated or downregulated (see Table 1).
Negative_regulation (downregulated) of miRNAs associated with cancer
11) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.31 Pain Relevance 0
In [21], expression profiling revealed that a number of miRNAs are differentially expressed in prostate cancer tissues including miR-21.
Negative_regulation (number) of miRNAs associated with prostate cancer
12) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.71 Pain Relevance 0.09
From the network, a number of upregulated and downregulated miRNAs obtained from the specific cancer tissue type are considered as the experimental data set.
Negative_regulation (downregulated) of miRNAs associated with cancer
13) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.42 Pain Relevance 0
In recent years a number of miRNAs are reported to be involved in various types of leukemia.
Negative_regulation (number) of miRNAs associated with leukemia
14) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.47 Pain Relevance 0
Loss or amplification of a number of miRNAs have been found related to lung cancer.
Negative_regulation (number) of miRNAs in lung associated with lung cancer
15) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.48 Pain Relevance 0
For example, in brain (central nervous system and glioblastoma) 94% of the miRNAs (79/84) are downregulated (P = 7.106 × 10-16, Fisher's exact test), and in hematogic, all the miRNAs (32/32) are downregulated (P = 1.642 × 10-8, Fisher's exact test); on the other hand 91.3% of the miRNAs (42/46) are upregulated in pancreatic cancer (P = 6.639 × 10-13, Fisher's exact test) and all the miRNAs (9/9) are upregulated in lymphoma (P = 4.228 × 10-4, Fisher's exact test).
Negative_regulation (downregulated) of miRNAs in central nervous system associated with lymphatic system cancer, glioblastoma, pancreatic cancer and central nervous system
16) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.90 Pain Relevance 0.05
A number of cancer types have been identified where a significant number of miRNAs are either upregulated or downregulated (see Table 1).
Negative_regulation (number) of miRNAs associated with cancer
17) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.29 Pain Relevance 0
It is hypothesized that the miRNAs downregulated in tumor tissues might be targeting oncogenes.
Negative_regulation (downregulated) of miRNAs associated with cancer
18) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.84 Pain Relevance 0
Compared with normal peripheral blood CD4+ T cells, pairwise significance analysis of microarray data indicated that the expression levels of eight miRNAs (miR-363, miR-512-5P, miR-345-MM, miR-146a, miR-146b, miR-296, miR-133b and miR-150) were increased more than two-fold by a change in CD4+ T cells of SF from RA patients whereas eight miRNAs (miR-331, miR-29a, miR-26a, miR-498, miR-129, let-7a, let-7d and miR-21) were significantly downregulated (Figure 1a).
Negative_regulation (downregulated) of miRNAs in blood associated with rheumatoid arthritis
19) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.43 Pain Relevance 0.21
A number of miRNAs have been found to show a tissue-specific pattern during cancer development and viral infection.
Negative_regulation (number) of miRNAs associated with cancer and viral infection
20) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.91 Pain Relevance 0.03

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