INT217806

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.68
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EIF4E) translation (EIF4E) cytoplasm (EIF4E)
EIF4E (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 98.08 Very High Very High Very High
Colon Cancer 21 78.88 Quite High
Cancer 51 72.80 Quite High
Prostate Cancer 27 50.00 Quite Low
Apoptosis 2 21.76 Low Low
Solid Tumor 1 7.52 Low Low
Chronic Lymphoid Leukemia 2 6.28 Low Low
Disease 3 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of eIF4E resulted in a 89% loss of expression and, full knock-out simulations predicted a complete loss of cyclin D and PSA.


Gene_expression (Reduction) of eIF4E associated with targeted disruption
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.49 Pain Relevance 0
The hsa-miR-200c is strongly associated with overall patient survival (Figure 2). hsa-miR-200c can potentially regulate over 200 target genes including MAPKKK3, eIF-4E, RAS homologs, RNA polymerase II, and cyclin L1 based on bioinformatics analysis (John et al. 2004).
Gene_expression (homologs) of eIF-4E
2) Confidence 0.03 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.19 Pain Relevance 0

General Comments

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