INT217807

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 18.57
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
Anatomy Link Frequency
colon 3
extracellular matrix 1
lung 1
ovary 1
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 56 99.64 Very High Very High Very High
Inflammation 14 71.52 Quite High
Chronic pancreatitis 28 71.36 Quite High
Central nervous system 14 51.76 Quite High
Spinal cord 14 48.88 Quite Low
endometriosis 29 48.04 Quite Low
cytokine 12 35.04 Quite Low
pain pelvic 2 23.60 Low Low
Bile 14 18.92 Low Low
Pain 14 11.60 Low Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 140 100.00 Very High Very High Very High
Pancreatic Cancer 196 99.84 Very High Very High Very High
Reprotox - General 3 158 99.84 Very High Very High Very High
Colon Cancer 140 99.84 Very High Very High Very High
Cancer 2531 99.64 Very High Very High Very High
Rheumatoid Arthritis 56 99.64 Very High Very High Very High
Thyroid Neoplasm 126 99.20 Very High Very High Very High
Apoptosis 103 98.36 Very High Very High Very High
Prostate Cancer 280 95.60 Very High Very High Very High
Repression 13 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, cancer-miRNA network efficiently detect hub miRNAs dysregulated in many cancer types and identify cancer specific miRNAs.
Regulation (dysregulated) of miRNAs associated with cancer
1) Confidence 0.00 Published 2010 Journal Silenc Section Abstract Doc Link PMC2835996 Disease Relevance 1.11 Pain Relevance 0
Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene.
Regulation (deregulated) of miRNAs in colon associated with cancer and colon cancer
2) Confidence 0.00 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.42 Pain Relevance 0
In this study, the expression levels of 10 different miRNAs known to be deregulated based on our previous studies were quantified using miRNA specific qRT-PCR analysis.
Regulation (deregulated) of miRNAs
3) Confidence 0.00 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.45 Pain Relevance 0
Modulation of miRNAs will likely be a new frontier for cancer diagnosis and treatment (Hampton, 2005).


Regulation (Modulation) of miRNAs associated with cancer
4) Confidence 0.00 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.56 Pain Relevance 0
A number of miRNAs were discovered to be deregulated due to the loss of the p53 tumor suppressor in colon cancer cell lines.
Regulation (deregulated) of miRNAs in colon associated with cancer and colon cancer
5) Confidence 0.00 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.71 Pain Relevance 0
Determination of the combinatorial effects of dysregulated miRNAs in specific cancer type is still not uncovered due to the lack of knowledge on existing cancer-miRNA modules and it's associated common target onco/tumor suppressor genes.
Regulation (dysregulated) of miRNAs associated with cancer
6) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.06 Pain Relevance 0
In the present study we have reported a set of 44 miRNAs that are dysregulated in ULM.


Regulation (dysregulated) of miRNAs associated with reprotox - general 3
7) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.43 Pain Relevance 0
As is evident, a particular type of cancer may be associated with the dysregulation of several distinct miRNAs and conversely dysregulation of one miRNA can be associated with several cancer types.
Regulation (dysregulation) of miRNAs associated with cancer
8) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.25 Pain Relevance 0
In each module a number of miRNAs are found that are dysregulated in several cancer types.
Regulation (dysregulated) of miRNAs associated with cancer
9) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.51 Pain Relevance 0
Tissue specific dysregulation patterns of miRNAs
Regulation (dysregulation) of miRNAs
10) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.01 Pain Relevance 0.03
This leads to the development of a cancer-miRNA network that provides a global perspective on which miRNAs are dysregulated in which cancer type as well as the pattern of dysregulation, namely, upregulation or downregulation.
Regulation (dysregulated) of miRNAs associated with cancer
11) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.22 Pain Relevance 0
In our present study we found that, 46 miRNAs are dysregulated in pancreatic cancer among which a significant number of miRNAs are overexpressed (P = 6.639 × 10-13, for details see Table 1) showing that miRNAs tend to be upregulated in pancreatic tumor tissue.
Regulation (dysregulated) of miRNAs associated with pancreatic cancer
12) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.67 Pain Relevance 0.07
In this study, a comprehensive analysis of the combinatorial nature of miRNA dysregulation in cancer tissues has been carried out by detecting rules that identify a set of miRNAs dysregulated in several cancer types.
Regulation (dysregulated) of miRNAs associated with cancer
13) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.72 Pain Relevance 0
For example, in module two, all the miRNAs are dysregulated in hematologic, breast, brain, cervical, colon, lung and ovary.
Regulation (dysregulated) of miRNAs in ovary
14) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.67 Pain Relevance 0
In this article an indepth survey has been conducted on the dysregulation of specific miRNAs in different cancers.
Regulation (dysregulation) of miRNAs associated with cancer
15) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.20 Pain Relevance 0
Thrombospondin 1 (THBS1), that is known to be antiproliferative, a protein inhibitor of angiogenesis, and a strong immune stimulator that can regulate T cell migration through extracellular matrix, is a potential target of multiple KSHV miRNAs and is translationally repressed in the presence of KSHV miRNAs like miR-k12-1, miR-k12-3-3p and miR-k12-6-3p.
Regulation (target) of miRNAs in extracellular matrix associated with herpes simplex virus
16) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 2.19 Pain Relevance 0
Computational predictions indicate that up to 30% of human genes are potential targets of miRNAs and that miRNAs compose 1%–5% of animal genomes [26–29].
Regulation (targets) of miRNAs
17) Confidence 0.00 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2837904 Disease Relevance 0.58 Pain Relevance 0.04
According to the results of microarray analysis, we focused on verifying the expression of those miRNAs whose expression levels were altered in both RA patients (Figure 1b).
Regulation (altered) of miRNAs associated with rheumatoid arthritis
18) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.46 Pain Relevance 0.23
For example, in module two, all the miRNAs are dysregulated in hematologic, breast, brain, cervical, colon, lung and ovary.
Regulation (dysregulated) of miRNAs in colon
19) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.67 Pain Relevance 0
For example, in module two, all the miRNAs are dysregulated in hematologic, breast, brain, cervical, colon, lung and ovary.
Regulation (dysregulated) of miRNAs in lung
20) Confidence 0.00 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.67 Pain Relevance 0

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