INT217814

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 19
Disease Relevance 7.94
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymph nodes 2
bone marrow 2
heart 2
immature T cells 2
B cells 1
MIR181A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 50 99.48 Very High Very High Very High
cytokine 270 57.28 Quite High
Multiple sclerosis 1580 5.00 Very Low Very Low Very Low
Inflammation 280 5.00 Very Low Very Low Very Low
Central nervous system 271 5.00 Very Low Very Low Very Low
Inflammatory response 40 5.00 Very Low Very Low Very Low
Demyelination 40 5.00 Very Low Very Low Very Low
chemokine 30 5.00 Very Low Very Low Very Low
Spinal cord 21 5.00 Very Low Very Low Very Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 561 99.84 Very High Very High Very High
Colon Cancer 172 99.12 Very High Very High Very High
Myeloid Leukemia 3 98.84 Very High Very High Very High
Chronic Lymphoid Leukemia 21 98.44 Very High Very High Very High
Disease 710 94.00 High High
Leukemia 20 93.72 High High
Colorectal Cancer 17 93.68 High High
Hematological Disease 30 92.28 High High
Death 70 89.80 High High
Autoimmune Disease 460 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of the first miRNAs described to have a role in immune cell development was miR-181a which is highly expressed in thymus cells and expressed at lower levels in the heart, lymph nodes, and bone marrow [91, 94].
Gene_expression (expressed) of miR-181a in lymph nodes
1) Confidence 0.58 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
Increasing miR-181a expression in mature T cells augments the sensitivity to peptide antigens while inhibiting miR-181a expression in the immature T cells reduces sensitivity and impairs both positive selection and negative selection [94].
Gene_expression (expression) of miR-181a in immature T cells
2) Confidence 0.58 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.42 Pain Relevance 0.08
One of the first miRNAs described to have a role in immune cell development was miR-181a which is highly expressed in thymus cells and expressed at lower levels in the heart, lymph nodes, and bone marrow [91, 94].
Gene_expression (expressed) of miR-181a in lymph nodes
3) Confidence 0.58 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
Moreover, miR-181a was identified as a positive regulator of B lymphocyte differentiation based on evidence that expression of miR-181a in hematopoietic stem and progenitor cells resulted in an increase in CD19+ B cells and a decrease in CD8+ T cells [91].
Gene_expression (expression) of miR-181a in stem
4) Confidence 0.58 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.07 Pain Relevance 0
In [34], it has been shown that miR-181a family miRNAs are expressed at relatively low levels in AML.
Gene_expression (expressed) of miR-181a associated with myeloid leukemia
5) Confidence 0.58 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.40 Pain Relevance 0
In bone marrow-derived B cells, miR-181a expression has been shown to decrease during B cell development from the pro-B to the pre-B cell stage [91]. miR-181a inhibits the transition of pro-B to the pre-B cell stage.
Gene_expression (expression) of miR-181a in B cells
6) Confidence 0.58 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
Increasing miR-181a expression in mature T cells augments the sensitivity to peptide antigens while inhibiting miR-181a expression in the immature T cells reduces sensitivity and impairs both positive selection and negative selection [94].
Gene_expression (expression) of miR-181a in immature T cells
7) Confidence 0.58 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.40 Pain Relevance 0.07
Among the ten miRNAs, hsa-miR-15b (p = 0.0278), hsa-miR-181b (p = 0.0002), hsa-miR-191 (p = 0.0264) and hsa-miR-200c (p = 0.0017) were significantly over-expressed in tumors compared to normal colorectal samples.
Gene_expression (expressed) of hsa-miR-181b associated with cancer
8) Confidence 0.29 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.60 Pain Relevance 0
In the current study, the expression levels of ten miRNAs (hsa-miR-30a-5p, hsa-miR-181b, hsa-let-7g, hsa-miR-26a, hsa-let-7b, has-miR-15b, has-miR-27a, has-miR-200c, has-miR-191, and has-miR-30c) were investigated to evaluate their clinical relevance in colorectal cancer. 24 normal and paired colorectal cancer specimens were selected as a model for this investigation.
Spec (investigated) Gene_expression (expression) of hsa-miR-181b associated with colon cancer
9) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.96 Pain Relevance 0
The expression of hsa-miR-15b, hsa-miR-181b, hsa-miR-191 and hsa-miR-200c were significantly over-expressed in colorectal cancer patients and they may be associated with the development of the disease.
Gene_expression (expression) of hsa-miR-181b associated with colon cancer and disease
10) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.82 Pain Relevance 0
The expression of hsa-miR-181b was elevated 2.5-fold (Median: 1.54 vs. 0.61, p = 0.0002) in tumor samples (Figure 2).
Gene_expression (expression) of hsa-miR-181b associated with cancer
11) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.57 Pain Relevance 0
The expression of hsa-miR-181b was 3.4-fold higher in 11 tumors with p53 mutations/deletions than the corresponding normal samples with wild type p53 and was strongly associated with p53 mutation status (median: 1.72 vs. 0.50, p = 0.0098) (Figure 4A).
Gene_expression (expression) of hsa-miR-181b associated with cancer
12) Confidence 0.29 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.52 Pain Relevance 0
Ten miRNAs (hsa-let-7b, hsa-let-7g, hsa-miR-15b, hsa-miR-181b, hsa-miR-191, hsa-miR-200c, hsa-miR-26a, hsa-miR-27a, hsa-miR-30a-5p and hsa-miR-30c) were evaluated for their potential prognostic value in colorectal cancer patients.
Gene_expression (hsa) of hsa-miR-181b associated with colon cancer
13) Confidence 0.25 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.52 Pain Relevance 0
Among the tumors with mutated p53, both hsa-miR-181b (Figure 4A) and hsa-miR-200c (Figure 4B) were highly over-expressed compared to the paired normal samples.
Gene_expression (expressed) of hsa-miR-181b associated with cancer
14) Confidence 0.22 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.56 Pain Relevance 0
Sequencing analysis revealed that hsa-miR-181b (p = 0.0098) and hsa-miR-200c (p = 0.0322) expression were strongly associated with the mutation status of the p53 tumor suppressor gene.
Gene_expression (expression) of hsa-miR-181b associated with cancer
15) Confidence 0.22 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.46 Pain Relevance 0
One of the first miRNAs described to have a role in immune cell development was miR-181a which is highly expressed in thymus cells and expressed at lower levels in the heart, lymph nodes, and bone marrow [91, 94].
Gene_expression (expressed) of miR-181a in heart
16) Confidence 0.20 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
One of the first miRNAs described to have a role in immune cell development was miR-181a which is highly expressed in thymus cells and expressed at lower levels in the heart, lymph nodes, and bone marrow [91, 94].
Gene_expression (expressed) of miR-181a in heart
17) Confidence 0.20 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
One of the first miRNAs described to have a role in immune cell development was miR-181a which is highly expressed in thymus cells and expressed at lower levels in the heart, lymph nodes, and bone marrow [91, 94].
Gene_expression (expressed) of miR-181a in bone marrow
18) Confidence 0.20 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0
One of the first miRNAs described to have a role in immune cell development was miR-181a which is highly expressed in thymus cells and expressed at lower levels in the heart, lymph nodes, and bone marrow [91, 94].
Gene_expression (expressed) of miR-181a in bone marrow
19) Confidence 0.20 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.09 Pain Relevance 0

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