INT21782

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 5.49
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (B2M) plasma membrane (B2M)
Anatomy Link Frequency
blood 2
plasma 1
hip 1
B2M (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 50 99.20 Very High Very High Very High
carpal tunnel syndrome 12 97.96 Very High Very High Very High
headache 1 93.76 High High
Pain 9 92.44 High High
pruritus 1 88.40 High High
burning pain 1 82.64 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 3 100.00 Very High Very High Very High
Amyloidosis 15 99.84 Very High Very High Very High
Osteoarthritis 56 99.20 Very High Very High Very High
Frailty 2 98.72 Very High Very High Very High
Spondylarthropathies 4 98.24 Very High Very High Very High
Carpal Tunnel Syndrome 13 97.96 Very High Very High Very High
Arthropathy 7 97.32 Very High Very High Very High
Amyloid Plaque 2 96.76 Very High Very High Very High
Headache 1 93.76 High High
Pain 5 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The used dialyzers MLW 1.3/1.8 m2 did not eliminate the beta 2-microglobulin from the blood.
Neg (not) Negative_regulation (eliminate) of beta 2-microglobulin in blood
1) Confidence 0.46 Published 1989 Journal Z Urol Nephrol Section Abstract Doc Link 2665386 Disease Relevance 0.38 Pain Relevance 0.09
Histology documented osseous and periarticular deposition of beta 2 microglobulin derived amyloid.
Negative_regulation (deposition) of beta 2 microglobulin associated with alzheimer's dementia
2) Confidence 0.42 Published 1990 Journal J Neuroradiol Section Abstract Doc Link 2201755 Disease Relevance 0.45 Pain Relevance 0.09
A Lixelle adsorption column for beta2-microglobulin removal was also introduced and the serum concentration of the beta-microglobulin was maintained at under 20 mg/dl.
Negative_regulation (removal) of beta2-microglobulin
3) Confidence 0.41 Published 2000 Journal Clin. Nephrol. Section Abstract Doc Link 10749305 Disease Relevance 0.15 Pain Relevance 0.15
Analysis of the sample groups together identified reduced expression stability (0.59) of the two optimal reference genes (TBP and B2M).
Negative_regulation (reduced) of B2M
4) Confidence 0.36 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.38 Pain Relevance 0.19
Nevertheless, reduction of the plasma beta 2-microglobulin was greater during push/pull HDF than during HD.
Negative_regulation (reduction) of plasma beta 2-microglobulin in plasma
5) Confidence 0.36 Published 1990 Journal Artif Organs Section Abstract Doc Link 2241598 Disease Relevance 0.31 Pain Relevance 0.31
Our data confirm the presence of beta 2-microglobulin in haemodialysis-associated amyloidosis, and also suggest a possible role for alpha 2-microglobulin: it may protect beta 2-microglobulin from proteolytic digestion, leading to its accumulation in intact form and to amyloid fibril formation.
Negative_regulation (presence) of 2-microglobulin associated with amyloidosis and alzheimer's dementia
6) Confidence 0.36 Published 1989 Journal Clin. Sci. Section Abstract Doc Link 2470544 Disease Relevance 0.51 Pain Relevance 0.08
The CT results demonstrated a notable decrease in gene expression for B2M and YWHAZ from the OA sample group (Figure 2).
Negative_regulation (decrease) of B2M associated with osteoarthritis
7) Confidence 0.31 Published 2007 Journal BMC Vet Res Section Body Doc Link PMC1884148 Disease Relevance 0.37 Pain Relevance 0.19
Recently CTS has been regarded as one of the major clinical manifestations of dialysis-related amyloidosis due to beta 2-microglobulin deposition and recognized with increasing frequency in patients undergoing long-term hemodialysis.
Negative_regulation (deposition) of beta 2-microglobulin associated with amyloidosis and carpal tunnel syndrome
8) Confidence 0.20 Published 1997 Journal Korean J. Intern. Med. Section Abstract Doc Link 9159043 Disease Relevance 1.13 Pain Relevance 0.60
Beta 2-microglobulin amyloid was found to be present in one patient operated on for hip fracture 2 yr after receiving a well-functioning transplant.
Negative_regulation (present) of 2-microglobulin in hip associated with frailty and alzheimer's dementia
9) Confidence 0.14 Published 1996 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 8738817 Disease Relevance 1.11 Pain Relevance 0.07
No effects on changes in CD4 cell counts, viral load, or proviral DNA frequency were observed among the four dosage groups, although a decline in beta 2-microglobulin levels was apparent in the highest dosage group.
Negative_regulation (decline) of 2-microglobulin
10) Confidence 0.04 Published 1994 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 7907662 Disease Relevance 0.24 Pain Relevance 0.14
There were no statistically significant differences in the pre-dialysis blood chemistry values or eKt/V at the four study time-points, but beta2-microglobulin levels significantly decreased (P < 0.03); the decrease in CRP levels was not significant (P < 0.06).
Negative_regulation (decreased) of beta2-microglobulin in blood
11) Confidence 0.01 Published 2007 Journal Nephrol. Dial. Transplant. Section Body Doc Link 17586845 Disease Relevance 0.22 Pain Relevance 0
RESULTS: The addition of pamidronate to chemotherapy resulted in a significant reduction of NTx, IL-6 and paraprotein from the 3rd month and of beta2-microglobulin, CRP and pain from the 6th month of treatment.
Negative_regulation (reduction) of beta2-microglobulin
12) Confidence 0.01 Published 2000 Journal Eur. J. Haematol. Section Body Doc Link 11092464 Disease Relevance 0.24 Pain Relevance 0

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