INT217820

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 46 99.96 Very High Very High Very High
Colon Cancer 21 99.16 Very High Very High Very High
Apoptosis 37 99.08 Very High Very High Very High
Multiple Myeloma 2 97.58 Very High Very High Very High
Lung Cancer 12 78.96 Quite High
Solid Tumor 2 69.92 Quite High
Drug Induced Neurotoxicity 1 46.04 Quite Low
Stress 3 44.12 Quite Low
Repression 2 13.24 Low Low
Acute Promyelocytic Leukemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A number of miRNAs were discovered to be deregulated due to the loss of the p53 tumor suppressor in colon cancer cell lines.
Regulation (deregulated) of Negative_regulation (loss) of p53 in colon associated with cancer and colon cancer
1) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.72 Pain Relevance 0
They stated that the multiple myeloma cells with normal p53 were resistant to arsenic trioxide-induced apoptosis and were arrested in G1 phase, whereas cells lacking functional p53 were sensitive and were arrested in G2/M phase [33].
Regulation (sensitive) of Negative_regulation (lacking) of p53 associated with apoptosis and multiple myeloma
2) Confidence 0.06 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 1.20 Pain Relevance 0

General Comments

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