INT217823

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.10
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
Anatomy Link Frequency
synovium 2
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 112 99.58 Very High Very High Very High
Inflammation 26 93.68 High High
Chronic pancreatitis 4 77.92 Quite High
psoriasis 4 76.08 Quite High
palliative 5 50.24 Quite High
cytokine 24 27.96 Quite Low
Pain 2 21.80 Low Low
Arthritis 2 7.60 Low Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 113 99.92 Very High Very High Very High
Rheumatoid Arthritis 112 99.58 Very High Very High Very High
Pancreatic Cancer 28 99.26 Very High Very High Very High
Reprotox - General 3 22 98.88 Very High Very High Very High
Cancer 539 98.76 Very High Very High Very High
Apoptosis 68 95.12 Very High Very High Very High
INFLAMMATION 26 93.68 High High
Repression 16 90.80 High High
Colorectal Cancer 12 90.00 High High
Thyroid Neoplasm 18 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of these miRNAs may be due to the loss of p53 tumor suppressor function in tumors.


Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miRNAs associated with cancer
1) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.91 Pain Relevance 0.05
Four of the ten miRNAs were overexpressed in colorectal cancer samples (Figure 1).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miRNAs associated with colon cancer
2) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.41 Pain Relevance 0
Overexpression of miRNAs in Colorectal Cancer
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miRNAs associated with colon cancer
3) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.38 Pain Relevance 0
Among these, four miRNAs were found to be overexpressed in colorectal cancer samples.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miRNAs associated with colon cancer
4) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.48 Pain Relevance 0
To further evaluate the clinical relevance of these overexpressed miRNAs in colorectal cancer in terms of prognosis, Kaplan-Meier survival analysis was performed using patient overall survival.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miRNAs associated with colon cancer
5) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.62 Pain Relevance 0
Interestingly higher expression of these miRNAs was also observed in small ULM than large ULM.
Positive_regulation (higher) of Gene_expression (expression) of miRNAs associated with reprotox - general 3
6) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.54 Pain Relevance 0
In our present study we found that, 46 miRNAs are dysregulated in pancreatic cancer among which a significant number of miRNAs are overexpressed (P = 6.639 × 10-13, for details see Table 1) showing that miRNAs tend to be upregulated in pancreatic tumor tissue.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miRNAs associated with pancreatic cancer
7) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.66 Pain Relevance 0.08
The abnormal expression of miR-146 and miR-155 is also found in the synovium of RA patients, while the expression of these miRNAs is markedly upregulated in SF after stimulation with TNF-?
Positive_regulation (upregulated) of Gene_expression (expression) of miRNAs in synovium associated with rheumatoid arthritis
8) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.86 Pain Relevance 0.35
Previously, gene expression analysis has facilitated the identification of targets upon overexpressed plant miRNAs [41].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of miRNAs
9) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.23 Pain Relevance 0.07

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