INT217825

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 5.20
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
Anatomy Link Frequency
joint 2
T cell 2
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 99.80 Very High Very High Very High
Inflammation 66 99.76 Very High Very High Very High
rheumatoid arthritis 280 99.64 Very High Very High Very High
endometriosis 29 81.60 Quite High
psoriasis 10 76.16 Quite High
Arthritis 5 45.56 Quite Low
pain pelvic 2 40.32 Quite Low
corticosteroid 5 11.52 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 99.76 Very High Very High Very High
Rheumatoid Arthritis 280 99.64 Very High Very High Very High
Colon Cancer 21 99.20 Very High Very High Very High
Cancer 60 98.52 Very High Very High Very High
Chromosome Aberrations 1 97.60 Very High Very High Very High
Apoptosis 123 92.48 High High
Death 34 87.64 High High
Disease 51 85.36 High High
Repression 19 84.64 Quite High
Autoimmune Disease 30 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the expression levels of 10 different miRNAs known to be deregulated based on our previous studies were quantified using miRNA specific qRT-PCR analysis.
Regulation (deregulated) of Gene_expression (expression) of miRNAs
1) Confidence 0.00 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.45 Pain Relevance 0
Interestingly, miRNAs altered expression has been associated with tumorigenesis, and several studies have described differential expression of miRNAs in neoplastic versus normal tissue [34–38].
Regulation (altered) of Gene_expression (expression) of miRNAs
2) Confidence 0.00 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2837904 Disease Relevance 0.55 Pain Relevance 0.07
The correlation between altered expression of miRNAs and cytokine levels was determined by linear regression analysis.
Regulation (altered) of Gene_expression (expression) of miRNAs associated with cytokine
3) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911863 Disease Relevance 0.80 Pain Relevance 0.30
According to the results of microarray analysis, we focused on verifying the expression of those miRNAs whose expression levels were altered in both RA patients (Figure 1b).
Regulation (altered) of Gene_expression (expression) of miRNAs associated with rheumatoid arthritis
4) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.46 Pain Relevance 0.23
In particular, T cell-mediated immune responses are associated with changes in the expression of specific miRNAs.
Regulation (changes) of Gene_expression (expression) of miRNAs in T cell
5) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.98 Pain Relevance 0.26
[25,26], which indicate that the inflammatory milieu may alter the miRNAs expression in joint tissue.
Spec (may) Regulation (alter) of Gene_expression (expression) of miRNAs in joint associated with inflammation
6) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 0.90 Pain Relevance 0.35
In this study, we have selected the RA patients who did not have any DMARDs therapy because it is known that drug treatment can affect expression of miRNAs [32].
Regulation (affect) of Gene_expression (expression) of miRNAs associated with rheumatoid arthritis
7) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.05 Pain Relevance 0.26

General Comments

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