INT217857

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 3.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXADR) extracellular region (CXADR) cell adhesion (CXADR)
mitochondrion organization (CXADR) plasma membrane (CXADR) nucleus (CXADR)
Anatomy Link Frequency
CAR 14
CXADR (Homo sapiens)
AD5 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 70 41.20 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
isoflurane 14 5.00 Very Low Very Low Very Low
Potency 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 448 99.32 Very High Very High Very High
Viral Infection 28 88.00 High High
Cancer 364 86.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 56 82.52 Quite High
Disease 14 74.64 Quite High
Cytomegalovirus Infection 28 73.96 Quite High
Lung Cancer 14 70.08 Quite High
Adenocarcinoma 14 66.88 Quite High
Rhabdomyosarcoma 14 63.44 Quite High
Toxicity 14 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unmodified Ad5 viruses interact with their native receptor CAR via the fiber knob domain.
CAR Binding (interact) of Ad5 in CAR
1) Confidence 0.18 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.07 Pain Relevance 0
As shown in Fig. 2, binding of sCAR to Ad5.PTDtat is similar to that of unmodified Ad5, suggesting the genetically modified vector Ad5.PTDtat maintained its ability to interact with the Ad5 native receptor, CAR.


CAR Binding (interact) of Ad5 in CAR
2) Confidence 0.18 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.17 Pain Relevance 0
As shown in Fig. 2, binding of sCAR to Ad5.PTDtat is similar to that of unmodified Ad5, suggesting the genetically modified vector Ad5.PTDtat maintained its ability to interact with the Ad5 native receptor, CAR.


CAR Binding (interact) of Ad5 in CAR
3) Confidence 0.15 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.17 Pain Relevance 0
CAR-binding activity of Ad5.PTDtat
CAR Binding (activity) of Ad5 in CAR
4) Confidence 0.14 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.07 Pain Relevance 0
We thus examined whether incorporation of PTDtat into the knob domain interfered with the Ad5-CAR interaction.
CAR Binding (interaction) of Ad5 in CAR
5) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.07 Pain Relevance 0
As shown in Fig. 2, binding of sCAR to Ad5.PTDtat is similar to that of unmodified Ad5, suggesting the genetically modified vector Ad5.PTDtat maintained its ability to interact with the Ad5 native receptor, CAR.


CAR Binding (interact) of Ad5 in CAR
6) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.17 Pain Relevance 0
Our data showed the modification did not interfere with Ad5 binding to its native receptor CAR, suggesting Ad5 infection via the CAR pathway is retained.
CAR Binding (binding) of Ad5 in CAR associated with infection
7) Confidence 0.13 Published 2007 Journal Virol J Section Abstract Doc Link PMC2134930 Disease Relevance 0.45 Pain Relevance 0
Our data showed that a genetically modified Ad5 vector, Ad5.PTDtat, maintained the ability to interact with its native receptor CAR, and delivered transgenes into both high-CAR and low-CAR cells more efficiently than the unmodified Ad5 vector.
CAR Binding (interact) of Ad5 in CAR
8) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.37 Pain Relevance 0
Our data showed that a genetically modified Ad5 vector, Ad5.PTDtat, maintained the ability to interact with its native receptor CAR, and delivered transgenes into both high-CAR and low-CAR cells more efficiently than the unmodified Ad5 vector.
CAR Binding (interact) of Ad5 in CAR
9) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.41 Pain Relevance 0
We thus examined whether incorporation of PTDtat into the knob domain interfered with the Ad5-CAR interaction.
CAR Binding (interaction) of Ad5 in CAR
10) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.07 Pain Relevance 0
Our data showed that a genetically modified Ad5 vector, Ad5.PTDtat, maintained the ability to interact with its native receptor CAR, and delivered transgenes into both high-CAR and low-CAR cells more efficiently than the unmodified Ad5 vector.
CAR Binding (interact) of Ad5 in CAR
11) Confidence 0.13 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.37 Pain Relevance 0
Our data showed that a genetically modified Ad5 vector, Ad5.PTDtat, maintained the ability to interact with its native receptor CAR, and delivered transgenes into both high-CAR and low-CAR cells more efficiently than the unmodified Ad5 vector.
high-CAR Binding (interact) of Ad5 in CAR
12) Confidence 0.11 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.39 Pain Relevance 0
Our data showed that a genetically modified Ad5 vector, Ad5.PTDtat, maintained the ability to interact with its native receptor CAR, and delivered transgenes into both high-CAR and low-CAR cells more efficiently than the unmodified Ad5 vector.
low-CAR Binding (interact) of Ad5 in CAR
13) Confidence 0.11 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.39 Pain Relevance 0
Our data showed that a genetically modified Ad5 vector, Ad5.PTDtat, maintained the ability to interact with its native receptor CAR, and delivered transgenes into both high-CAR and low-CAR cells more efficiently than the unmodified Ad5 vector.
low-CAR Binding (interact) of Ad5 in CAR
14) Confidence 0.11 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.39 Pain Relevance 0

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