INT217886

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.61
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per2) nucleus (Per2) protein binding transcription factor activity (Per2)
cytoplasm (Per2) signal transducer activity (Per2)
Per2 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 129 99.36 Very High Very High Very High
GABAergic 13 64.00 Quite High
Dopamine 75 50.00 Quite Low
Angina 1 28.60 Quite Low
agonist 36 5.00 Very Low Very Low Very Low
antagonist 28 5.00 Very Low Very Low Very Low
tetrodotoxin 27 5.00 Very Low Very Low Very Low
Neurotransmitter 23 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
Action potential 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 85.60 High High
Sleep Disorders 37 75.60 Quite High
Cancer 13 73.60 Quite High
Breast Cancer 17 59.36 Quite High
Malignant Neoplastic Disease 1 41.48 Quite Low
Myocardial Infarction 1 29.68 Quite Low
Cv General 3 Under Development 1 28.60 Quite Low
Stroke 1 27.92 Quite Low
Cardiovascular Disease 3 27.32 Quite Low
Disease 15 24.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This complex then activates the transcription of thee Period genes known as Per1, Per2, and Per3.
Positive_regulation (activates) of Transcription (transcription) of Per2
1) Confidence 0.55 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 0.53 Pain Relevance 0
We also modeled a CRE element where a factor (e.g., CREB) can bind and activate transcription of Per1 and Per2 or a secreted CA.
Positive_regulation (activate) of Transcription (transcription) of Per2
2) Confidence 0.48 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2953532 Disease Relevance 0 Pain Relevance 0
Processes that increase the amount of Per2 produced (faster Per2 transcription or translation, or slower mRNA degradation) tend to lead to a longer period.
Positive_regulation (increase) of Transcription (transcription) of Per2
3) Confidence 0.44 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0 Pain Relevance 0
To determine the mechanisms by which GABA suppressed retinal PER2::LUC expression and rhythmicity, we first quantified Per1, Per2, Clock, and Bmal1 mRNA levels 8 h after 3 mM GABA treatment using quantitative real-time PCR.
Positive_regulation (quantified) of Transcription (levels) of Per2 associated with gaba
4) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.54
enhancer elements of Period genes (Per1, Per2, and Per3) and Cryptochrome gene (Cry1 and Cry2) promoters (Figure 1, (3)) [8, 12, 13] to activate transcription of Per and Cry [14].
Positive_regulation (activate) of Transcription (transcription) of Period
5) Confidence 0.41 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.09 Pain Relevance 0

General Comments

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