INT21789

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.26
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
plasma membrane (ERBB3) nucleus (ERBB3)
Anatomy Link Frequency
MDA-MB-231 3
MCF-7 1
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 88.00 High High
metalloproteinase 10 73.84 Quite High
Chronic pancreatitis 2 73.44 Quite High
withdrawal 4 50.24 Quite High
Inflammation 4 38.00 Quite Low
psoriasis 6 30.72 Quite Low
Central nervous system 21 5.00 Very Low Very Low Very Low
COX-2 inhibitor 21 5.00 Very Low Very Low Very Low
Mechanotransduction 8 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 116 100.00 Very High Very High Very High
Cancer 165 99.76 Very High Very High Very High
Metastasis 60 99.04 Very High Very High Very High
Colon Cancer 26 97.72 Very High Very High Very High
INFLAMMATION 6 86.56 High High
Injury 21 86.16 High High
Breast Cancer 115 85.80 High High
Starvation 2 83.76 Quite High
Adhesions 27 81.56 Quite High
Adenocarcinoma 5 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a similar contrasting increase in fos and ErbB3 levels was found in normal colonic cells as compared to colorectal cancers in a SAGE study [73].
Positive_regulation (increase) of ErbB3 associated with colon cancer
1) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.30 Pain Relevance 0
Surprisingly, ErbB3, which promotes proliferation through the Wnt signalling pathway, was also up-regulated.
Positive_regulation (up-regulated) of ErbB3
2) Confidence 0.44 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.20 Pain Relevance 0.06
Since the rat homologue (neu) of the c-erb B-2 oncogene may be activated by a specific point mutation in its transmembrane region, we have analysed 23 cases from this series for mutations by polymerase chain reaction amplification and sequence-specific oligonucleotide hybridization.
Spec (may) Positive_regulation (activated) of c-erb B-2
3) Confidence 0.36 Published 1990 Journal J. Pathol. Section Abstract Doc Link 2202801 Disease Relevance 0.51 Pain Relevance 0.14
Of 17 patients with a response, 16 appeared to have a gene expression signature that combined ERBB1, ERBB2 and ERBB3.
Positive_regulation (combined) of ERBB3
4) Confidence 0.19 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.28 Pain Relevance 0
M) induced apoptosis in MDA-MB-231 and MDA-MB-435 cells stably transfected with E1A.


Positive_regulation (induced) of MDA-MB-231 in MDA-MB-231 associated with apoptosis
5) Confidence 0.03 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.41 Pain Relevance 0.09
Expression of Gli2, a transcription factor known to regulate PTHrP [4], also showed a 5-fold increase on hard substrates in both MDA-MB-231 and RWGT2 (Figure 3) but not in MCF-7 cells (data not shown).
Positive_regulation (increase) of MDA-MB-231 in MDA-MB-231
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.25 Pain Relevance 0
In addition we also found a 70-, 5-, and 3-fold increase in the levels of 5-, 15- and 12-HETE respectively in MDA-MB-231 as compared to MCF-7 cells.
Positive_regulation (increase) of MDA-MB-231 in MCF-7
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.64 Pain Relevance 0
Ibandronate significantly decreased tumour burden and increased MDA-MB-231 cell apoptosis in bone metastases.
Positive_regulation (increased) of MDA-MB-231 in MDA-MB-231 associated with cancer, apoptosis and metastasis
8) Confidence 0.01 Published 2002 Journal Breast Cancer Res Section Body Doc Link PMC138711 Disease Relevance 1.68 Pain Relevance 0

General Comments

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