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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.14
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CSNK1A1) cytosol (CSNK1A1) mitosis (CSNK1A1)
signal transduction (CSNK1A1) chromosome (CSNK1A1) nucleus (CSNK1A1)
CSNK1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 50.92 Quite High
Ziconotide 1 39.84 Quite Low
Lasting pain 1 33.36 Quite Low
Inflammation 3 32.80 Quite Low
antagonist 8 27.00 Quite Low
Central nervous system 1 8.72 Low Low
cINOD 13 5.00 Very Low Very Low Very Low
Kinase C 7 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 99.62 Very High Very High Very High
Disease 27 96.88 Very High Very High Very High
Cancer 93 90.28 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 89.96 High High
Apoptosis 21 83.92 Quite High
Neuroblastoma 3 76.32 Quite High
Osteogenic Sarcomas 2 74.68 Quite High
Metastasis 4 72.80 Quite High
Thyroid Neoplasm 1 72.64 Quite High
Desmoid Disease 1 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A comparison with experimental results for period-related abnormalities reveals that PER2 phosphorylation by CK1 has significant involvement in setting the period.
Phosphorylation (phosphorylation) of CK1 associated with congenital anomalies
1) Confidence 0.54 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134962 Disease Relevance 0.10 Pain Relevance 0
These mutations affect specific serine and threonine residues, which are sites for priming by CK1 (Ser 45) and further phosphorylation by GSK3?
Phosphorylation (phosphorylation) of CK1
2) Confidence 0.20 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.50 Pain Relevance 0
In the course of screening for pharmacological inhibitors of disease-relevant protein kinases such as cyclin-dependent kinases (CDKs) [28, 29], glycogen synthase kinase-3 (GSK-3) [30], PIM1 [31], “dual-specificity, tyrosine phosphorylation regulated kinase 1A” (DYRK1A) [32–34], casein kinase 1 (CK1) [35], we discovered that several lamellarins inhibit the catalytic activity of some of these kinases.
Phosphorylation (phosphorylation) of CK1 associated with disease
3) Confidence 0.18 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 0.54 Pain Relevance 0.05

General Comments

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