INT21793

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Context Info
Confidence 0.70
First Reported 1986
Last Reported 2011
Negated 8
Speculated 4
Reported most in Abstract
Documents 154
Total Number 159
Disease Relevance 94.78
Pain Relevance 85.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)
Anatomy Link Frequency
nerve 29
neurons 10
bladder 8
cerebrospinal fluid 5
brain 5
Ngf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2179 100.00 Very High Very High Very High
substance P 172 100.00 Very High Very High Very High
cytokine 160 100.00 Very High Very High Very High
bDMF 158 100.00 Very High Very High Very High
Calcitonin gene-related peptide 118 100.00 Very High Very High Very High
Inflammatory mediators 43 100.00 Very High Very High Very High
Enkephalin 18 99.98 Very High Very High Very High
Inflammation 557 99.96 Very High Very High Very High
dorsal root ganglion 257 99.96 Very High Very High Very High
Serotonin 103 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 610 100.00 Very High Very High Very High
Injury 494 100.00 Very High Very High Very High
Cancer 226 100.00 Very High Very High Very High
Hypersensitivity 153 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Disease 1254 99.96 Very High Very High Very High
Ganglion Cysts 564 99.96 Very High Very High Very High
Brain Injury 310 99.96 Very High Very High Very High
Hyperalgesia 213 99.90 Very High Very High Very High
Salivary Gland Disease 21 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cutaneous leishmaniasis (CL) in mice has been shown to produce hyperalgesia and upregulation of interleukin (IL)-1beta and nerve growth factor (NGF) levels.
Positive_regulation (upregulation) of NGF in nerve associated with leishmaniasis, hyperalgesia and nerve growth factor
1) Confidence 0.70 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.91 Pain Relevance 0.64
Cutaneous leishmaniasis (CL) in mice has been shown to produce hyperalgesia and upregulation of interleukin (IL)-1beta and nerve growth factor (NGF) levels.
Positive_regulation (upregulation) of nerve growth factor in nerve associated with leishmaniasis, hyperalgesia and nerve growth factor
2) Confidence 0.70 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.91 Pain Relevance 0.64
Mice with CL showed sustained increase in the levels of IL-1beta and NGF which were reversed by thymulin (1 microg).
Positive_regulation (increase) of NGF associated with leishmaniasis and nerve growth factor
3) Confidence 0.70 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.92 Pain Relevance 0.80
We previously demonstrated that the i.p. injection of DADLE in mice causes an increase of nerve growth factor (NGF) in the brain.
Positive_regulation (increase) of nerve growth factor in brain associated with nerve growth factor
4) Confidence 0.70 Published 2005 Journal Synapse Section Abstract Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.64
Picomolar concentrations of hibernation induction delta opioid peptide [D-Ala2,D-Leu5]enkephalin increase the nerve growth factor in NG-108 cells.
Positive_regulation (increase) of nerve growth factor in nerve associated with nerve growth factor, enkephalin and opioid
5) Confidence 0.70 Published 2005 Journal Synapse Section Title Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.73
We previously demonstrated that the i.p. injection of DADLE in mice causes an increase of nerve growth factor (NGF) in the brain.
Positive_regulation (increase) of NGF in brain associated with nerve growth factor
6) Confidence 0.70 Published 2005 Journal Synapse Section Abstract Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.64
DADLE dose-dependently increases the immunoreactive level of NGF in NG-108 cells in a bell-shape manner, with the effective DADLE concentrations in the picomolar range (0.01-100 pM).
Positive_regulation (increases) of NGF associated with nerve growth factor
7) Confidence 0.70 Published 2005 Journal Synapse Section Abstract Doc Link 15945062 Disease Relevance 0 Pain Relevance 0.66
Using a line of transgenic mice overexpressing NGF among glial cells, it was first found that trigeminal ganglia from adult transgenic mice possessed significantly higher levels of NGF protein in comparison to age-matched wild-type mice; as well, detectable levels of NGF mRNA transgene expression were present in both the ganglia and brain stem.
Positive_regulation (levels) of NGF in glial cells associated with targeted disruption and nerve growth factor
8) Confidence 0.70 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9514524 Disease Relevance 0.50 Pain Relevance 0.62
From these data, we propose that accumulation of glial-derived NGF by adult sensory neurons and its putative release into the ganglionic environment induce the directional growth of sympathetic axons to the source of NGF, namely, the cell bodies of primary sensory neurons.
Positive_regulation (accumulation) of NGF in adult sensory neurons associated with nerve growth factor
9) Confidence 0.70 Published 1998 Journal J. Neurobiol. Section Abstract Doc Link 9514524 Disease Relevance 0.43 Pain Relevance 0.62
The results show that schistosomiasis induced granulomas in several regions of the CNS and increased nerve growth factor (NGF) levels in the cortex, hypothalamus and brain stem, but not in the hippocampus.
Neg (not) Positive_regulation (increased) of NGF in cortex associated with nerve growth factor, hippocampus, central nervous system, granuloma and schistosomiasis
10) Confidence 0.70 Published 1996 Journal Acta Neuropathol. Section Abstract Doc Link 8870833 Disease Relevance 0.85 Pain Relevance 0.57
The infection also caused paw hyperalgesia, as determined by the hot-plate test, and a local increase in NGF, but not in substance P.
Spec (determined) Positive_regulation (increase) of NGF in paw associated with hyperalgesia, nerve growth factor, infection and substance p
11) Confidence 0.70 Published 1996 Journal Acta Neuropathol. Section Abstract Doc Link 8870833 Disease Relevance 0.86 Pain Relevance 0.58
The results show that schistosomiasis induced granulomas in several regions of the CNS and increased nerve growth factor (NGF) levels in the cortex, hypothalamus and brain stem, but not in the hippocampus.
Neg (not) Positive_regulation (increased) of nerve growth factor in cortex associated with nerve growth factor, hippocampus, central nervous system, granuloma and schistosomiasis
12) Confidence 0.70 Published 1996 Journal Acta Neuropathol. Section Abstract Doc Link 8870833 Disease Relevance 0.85 Pain Relevance 0.56
Induction of NGF in the post-operative phase of pain was TNF-dependent as anti-TNF reduced NGF expression in the joint and abrogated pain.
Positive_regulation (Induction) of NGF in joint associated with pain and nerve growth factor
13) Confidence 0.70 Published 2010 Journal Pain Section Abstract Doc Link 20350782 Disease Relevance 1.56 Pain Relevance 1.93
Ovariectomy caused a significant decrease in NGF protein content in the uterus, and short term treatment of ovariectomized mice with estrogen and/or progesterone increased uterine NGF mRNA and restored NGF protein to concentrations similar to intact control mice.
Positive_regulation (increased) of NGF in uterus associated with nerve growth factor
14) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.14 Pain Relevance 0.52
NGF mRNA was increased in salivary glands from ovariectomized mice treated with progesterone alone or in combination with estrogen relative to other groups.
Positive_regulation (increased) of NGF in salivary glands associated with nerve growth factor and salivary gland disease
15) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.15 Pain Relevance 0.55
Ovariectomy caused a significant decrease in NGF protein content in the uterus, and short term treatment of ovariectomized mice with estrogen and/or progesterone increased uterine NGF mRNA and restored NGF protein to concentrations similar to intact control mice.
Positive_regulation (restored) of NGF protein in uterus associated with nerve growth factor
16) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11882380 Disease Relevance 0.14 Pain Relevance 0.52
Using a murine model of CL we report on evident hyperalgesia, as assessed by acute pain tests, and sustained upregulation of interleukin (IL-1beta) and nerve growth factor (NGF).
Positive_regulation (upregulation) of nerve growth factor in nerve associated with leishmaniasis, hyperalgesia, nerve growth factor and acute pain
17) Confidence 0.69 Published 2000 Journal Pain Section Abstract Doc Link 10781922 Disease Relevance 1.00 Pain Relevance 0.86
Using a murine model of CL we report on evident hyperalgesia, as assessed by acute pain tests, and sustained upregulation of interleukin (IL-1beta) and nerve growth factor (NGF).
Positive_regulation (upregulation) of NGF in nerve associated with leishmaniasis, hyperalgesia, nerve growth factor and acute pain
18) Confidence 0.69 Published 2000 Journal Pain Section Abstract Doc Link 10781922 Disease Relevance 1.00 Pain Relevance 0.86
RA can revert functional and ultrastructural changes and induce neural regeneration after the establishment of diabetic neuropathy, possibly because of the increased of NGF concentrations in nerve terminals.
Spec (possibly) Positive_regulation (increased) of NGF in neural associated with diabetic neuropathy and rheumatoid arthritis
19) Confidence 0.69 Published 2008 Journal Transl Res Section Abstract Doc Link 18593635 Disease Relevance 1.84 Pain Relevance 0.30
Animals with DM + RA had a significant increase of NGF in nerves as compared with the other groups.
Positive_regulation (increase) of NGF in nerves associated with diabetes mellitus and rheumatoid arthritis
20) Confidence 0.69 Published 2008 Journal Transl Res Section Abstract Doc Link 18593635 Disease Relevance 2.15 Pain Relevance 0.36

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