INT21794

Context Info Confidence 0.70 First Reported 1990 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 20 Total Number 21 Disease Relevance 8.44 Pain Relevance 9.30

extracellular space (Npy) extracellular region (Npy)

Anatomy Link Frequency brain 4 PVN 4 hippocampus 4 neurons 4 ventral 3 Npy (Mus musculus)

Pain Link Frequency Relevance Heat Neuropeptide 129 100.00 Enkephalin 41 100.00 Cholecystokinin 29 100.00 Hippocampus 17 99.84 dorsal root ganglion 7 99.84 opioid receptor 2 98.48 amygdala 18 96.64 rheumatoid arthritis 1 96.28 Limbic system 1 95.68 bradykinin 5 95.36

Disease Link Frequency Relevance Heat Convulsion 96 99.98 Ganglion Cysts 8 99.84 Targeted Disruption 38 97.84 Rheumatoid Arthritis 2 96.28 Appetite Loss 24 96.12 Neurological Disease 4 95.84 Systemic Lupus Erythematosus 2 95.08 Stress 55 94.96 Death 11 94.60 Disease 26 93.88

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Between 110 and 140 days postinoculation NPY mRNA expression was specifically up-regulated in CA3 pyramidal neurones, whereas expression of NPY in hilar neurones remained unaltered.

Positive_regulation (up-regulated) of Gene_expression (expression) of NPY mRNA

1) Confidence 0.70 Published 1996 Journal Neuroreport Section Abstract Doc Link 8905686 Disease Relevance 0.31 Pain Relevance 0.36

Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice.

Spec (might) Positive_regulation (contribute) of Gene_expression (expression) of neuropeptide Y mRNA associated with targeted disruption, neuropeptide and opioid receptor

2) Confidence 0.62 Published 2006 Journal Neuroreport Section Abstract Doc Link 16738492 Disease Relevance 0.61 Pain Relevance 0.34

In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2.

Positive_regulation (changes) of Gene_expression (expression) of NPY associated with neuropeptide

3) Confidence 0.50 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15930374 Disease Relevance 0.67 Pain Relevance 0.41

These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels.

Positive_regulation (enhanced) of Gene_expression (synthesis) of NPY in neurons associated with enkephalin

4) Confidence 0.49 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680430 Disease Relevance 0.09 Pain Relevance 0.63

In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2.

Positive_regulation (increased) of Gene_expression (expression) of neuropeptide Y mRNA associated with neuropeptide

5) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15930374 Disease Relevance 0.67 Pain Relevance 0.41

Expression of NPY and NPY receptors is changed in the hippocampus of mice comparatively early after prion inoculation, indicating that this peptide system is affected in this spongiform degenerative disease in a region of importance for learning and memory.

Positive_regulation (changed) of Gene_expression (Expression) of NPY in hippocampus associated with hippocampus and disease

6) Confidence 0.46 Published 1999 Journal Horm. Metab. Res. Section Abstract Doc Link 10422730 Disease Relevance 0.43 Pain Relevance 0.46

Plasma levels of NPY are reported to be elevated in other complex multi-symptom illnesses associated with immunologic dysfunction, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [33].

Positive_regulation (elevated) of Gene_expression (levels) of NPY in Plasma associated with rheumatoid arthritis and systemic lupus erythematosus

7) Confidence 0.46 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC3024290 Disease Relevance 1.29 Pain Relevance 0.41

A similar increasing sensitivity to exogenous PYY and NPY has also been described from the small to the large intestine of the mouse (Cox et al., 2001).

Positive_regulation (increasing) of Gene_expression (exogenous) of NPY in large intestine

8) Confidence 0.43 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2890049 Disease Relevance 0.08 Pain Relevance 0.05

Recurrent seizures induce two temporally distinct changes in NPY expression in hippocampus.

Positive_regulation (induce) of Gene_expression (expression) of NPY in hippocampus associated with convulsion and hippocampus

9) Confidence 0.39 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.77 Pain Relevance 0.68

Increased NPY expression was not seen in P30, P60 and P90 N1F2 B6;129-Scn9aN641Y/N641Y or N1F2 B6;129-Scn9aN641Y/+ mice (data not shown).

Positive_regulation (Increased) of Gene_expression (expression) of NPY

10) Confidence 0.36 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.88 Pain Relevance 0.11

Based on the published data cited above, we would have expected to see increased Npy and decreased Crh expression in the hypothalami of deprived pups.

Positive_regulation (increased) of Gene_expression (expression) of Npy

11) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.23 Pain Relevance 0.03

In mc4r ko mice, or lethal yellow mice overexpressing agouti, NPY expression (but not galanin or POMC) is significantly elevated in the DMH.

Positive_regulation (elevated) of Gene_expression (expression) of NPY

12) Confidence 0.31 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.07 Pain Relevance 0.08

For example, in hypothalamic explant experiments injection of MCH into the hypothalamus increased the production of NPY and AgRP and decreased the production of MSH and CART, as measured by radioimmunoassay [153].

Positive_regulation (increased) of Gene_expression (production) of NPY in hypothalamus

13) Confidence 0.31 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.14 Pain Relevance 0.15

Neuropeptides, such as galanin, neuropeptide Y (NPY), and pituitary adenylyl cyclase activating polypeptide (PACAP), which are normally expressed at low levels in sensory neurons, are dramatically increased in DRG neurons, including medium to large size neurons (A-fibers) [26-29].

Positive_regulation (increased) of Gene_expression (expressed) of NPY in pituitary associated with dorsal root ganglion and neuropeptide

14) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.30 Pain Relevance 1.30

Neuronal migrations towards the cortex and basal ganglia were greatly reduced in mutants, causing a periventricular accumulation of NPY+ (neuropeptide Y) or calretinin+ neurons in the MGE.

Positive_regulation (accumulation) of Gene_expression (neurons) of NPY in neurons associated with neuropeptide

15) Confidence 0.23 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2841486 Disease Relevance 0.11 Pain Relevance 0.27

Expression of cholecystokinin, enkephalin, galanin and neuropeptide Y is markedly changed in the brain of the megencephaly mouse.

Positive_regulation (changed) of Gene_expression (Expression) of neuropeptide Y in brain associated with neuropeptide, enkephalin and cholecystokinin

16) Confidence 0.13 Published 2000 Journal Neuroscience Section Title Doc Link 11008168 Disease Relevance 0.28 Pain Relevance 0.69

Here, we report that expression of the neuropeptides cholecystokinin, enkephalin, galanin and neuropeptide Y is dramatically changed in mceph/mceph brains compared to wild type, as revealed by in situ hybridization and immunohistochemistry.

Positive_regulation (changed) of Gene_expression (expression) of neuropeptide Y in brains associated with neuropeptide, enkephalin and cholecystokinin

17) Confidence 0.12 Published 2000 Journal Neuroscience Section Abstract Doc Link 11008168 Disease Relevance 0.28 Pain Relevance 0.56

Neuropeptide Y expression was increased in the hippocampal formation and ventral cortices.

Positive_regulation (increased) of Gene_expression (expression) of Neuropeptide Y in ventral associated with neuropeptide

18) Confidence 0.10 Published 2000 Journal Neuroscience Section Abstract Doc Link 11008168 Disease Relevance 0.11 Pain Relevance 0.61

The second problem, with overexpression of neuropeptides via viral vectors, is that the neuropeptide is potentially released in an area to which the transduced neuron projects rather than secretion locally at the site of transduction; with AAV mediated overexpression of neuropeptide Y (NPY) in the paraventricular nucleus (PVN) [13,16] the release of NPY may thus not be limited to the PVN.

Positive_regulation (mediated) of Gene_expression (overexpression) of neuropeptide Y in PVN associated with neuropeptide

19) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.57

The second problem, with overexpression of neuropeptides via viral vectors, is that the neuropeptide is potentially released in an area to which the transduced neuron projects rather than secretion locally at the site of transduction; with AAV mediated overexpression of neuropeptide Y (NPY) in the paraventricular nucleus (PVN) [13,16] the release of NPY may thus not be limited to the PVN.

Positive_regulation (overexpression) of Gene_expression (overexpression) of neuropeptide Y in PVN associated with neuropeptide

20) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2928777 Disease Relevance 0 Pain Relevance 0.57

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