INT21794
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Between 110 and 140 days postinoculation NPY mRNA expression was specifically up-regulated in CA3 pyramidal neurones, whereas expression of NPY in hilar neurones remained unaltered. | |||||||||||||||
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Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice. | |||||||||||||||
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In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2. | |||||||||||||||
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These results suggest that the synthesis of NPY, ENK and NT is enhanced in TIDA neurons during lactation and that these neuromessengers may be co-released together with DA from the ME to regulate the suckling-induced prolactin secretion at the hypothalamic and/or pituitary levels. | |||||||||||||||
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In addition, these METH injections were associated with increased expression of neuropeptide Y mRNA and changes in the expression of the NPY receptors Y1 and Y2. | |||||||||||||||
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Expression of NPY and NPY receptors is changed in the hippocampus of mice comparatively early after prion inoculation, indicating that this peptide system is affected in this spongiform degenerative disease in a region of importance for learning and memory. | |||||||||||||||
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Plasma levels of NPY are reported to be elevated in other complex multi-symptom illnesses associated with immunologic dysfunction, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) [33]. | |||||||||||||||
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A similar increasing sensitivity to exogenous PYY and NPY has also been described from the small to the large intestine of the mouse (Cox et al., 2001). | |||||||||||||||
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Recurrent seizures induce two temporally distinct changes in NPY expression in hippocampus. | |||||||||||||||
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Increased NPY expression was not seen in P30, P60 and P90 N1F2 B6;129-Scn9aN641Y/N641Y or N1F2 B6;129-Scn9aN641Y/+ mice (data not shown). | |||||||||||||||
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Based on the published data cited above, we would have expected to see increased Npy and decreased Crh expression in the hypothalami of deprived pups. | |||||||||||||||
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In mc4r ko mice, or lethal yellow mice overexpressing agouti, NPY expression (but not galanin or POMC) is significantly elevated in the DMH. | |||||||||||||||
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For example, in hypothalamic explant experiments injection of MCH into the hypothalamus increased the production of NPY and AgRP and decreased the production of MSH and CART, as measured by radioimmunoassay [153].
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Neuropeptides, such as galanin, neuropeptide Y (NPY), and pituitary adenylyl cyclase activating polypeptide (PACAP), which are normally expressed at low levels in sensory neurons, are dramatically increased in DRG neurons, including medium to large size neurons (A-fibers) [26-29]. | |||||||||||||||
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Neuronal migrations towards the cortex and basal ganglia were greatly reduced in mutants, causing a periventricular accumulation of NPY+ (neuropeptide Y) or calretinin+ neurons in the MGE. | |||||||||||||||
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Expression of cholecystokinin, enkephalin, galanin and neuropeptide Y is markedly changed in the brain of the megencephaly mouse. | |||||||||||||||
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Here, we report that expression of the neuropeptides cholecystokinin, enkephalin, galanin and neuropeptide Y is dramatically changed in mceph/mceph brains compared to wild type, as revealed by in situ hybridization and immunohistochemistry. | |||||||||||||||
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Neuropeptide Y expression was increased in the hippocampal formation and ventral cortices. | |||||||||||||||
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The second problem, with overexpression of neuropeptides via viral vectors, is that the neuropeptide is potentially released in an area to which the transduced neuron projects rather than secretion locally at the site of transduction; with AAV mediated overexpression of neuropeptide Y (NPY) in the paraventricular nucleus (PVN) [13,16] the release of NPY may thus not be limited to the PVN. | |||||||||||||||
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The second problem, with overexpression of neuropeptides via viral vectors, is that the neuropeptide is potentially released in an area to which the transduced neuron projects rather than secretion locally at the site of transduction; with AAV mediated overexpression of neuropeptide Y (NPY) in the paraventricular nucleus (PVN) [13,16] the release of NPY may thus not be limited to the PVN. | |||||||||||||||
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