INT21795

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.94
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
pyramidal cells 1
interneurons 1
granule cells 1
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 4 98.24 Very High Very High Very High
Cholecystokinin 16 93.24 High High
Hippocampus 15 93.12 High High
Neuropeptide 29 92.00 High High
cocaine 3 88.52 High High
Opioid 6 85.00 Quite High
Pain 4 75.92 Quite High
Dynorphin 5 75.04 Quite High
trigeminal ganglion 1 75.00 Quite High
Face pain 1 74.64 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 1 91.20 High High
Convulsion 37 90.24 High High
Neurodegenerative Disease 2 79.00 Quite High
Pain 2 75.92 Quite High
Obesity 67 75.56 Quite High
Ganglion Cysts 1 75.00 Quite High
Facial Pain 1 74.64 Quite High
Temporomandibular Joint Syndrome 1 69.28 Quite High
Migraine Disorders 1 68.16 Quite High
Body Weight 43 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is followed by the seemingly novel appearance of preproNPY mRNA within the dentate gyrus granule cells and pyramidal cells of field CA1.
Transcription (appearance) of preproNPY mRNA in pyramidal cells associated with pyramidal cell
1) Confidence 0.57 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.79 Pain Relevance 0.65
CGRP and ANP mRNAs did not change across the estrous cycle, while expression of galanin and NPY mRNAs were strongly linked to the estrous cycle.
Transcription (expression) of NPY
2) Confidence 0.52 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15936815 Disease Relevance 0.49 Pain Relevance 0.63
Therefore hypothalamic AGRP and POMC mRNAs were both induced by the glucocorticoid implant, whereas the NPY mRNA was not significantly influenced.


Neg (not) Transcription (influenced) of NPY
3) Confidence 0.50 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.18 Pain Relevance 0
Hypothalamic NPY mRNA exhibited a trend toward an increase although the effect was not significant (p = 0.14; Fig. 6C).
Transcription (exhibited) of NPY
4) Confidence 0.50 Published 2003 Journal BMC Physiol Section Body Doc Link PMC179893 Disease Relevance 0.20 Pain Relevance 0
Fasting activates mRNA expression in hypothalamic NPY neurones [51].
Transcription (expression) of NPY
5) Confidence 0.38 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.15 Pain Relevance 0.07
NPY+ fibers and interneurons were fairly evenly distributed in the WT mouse HF (Figure 6C), but NPY-ir was strongly increased in SLu and the polymorph layer of neo-excised SNAP-25b deficient mutants (Figure 6D and 6H, c.f.
Transcription (distributed) of NPY in interneurons
6) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.33 Pain Relevance 0.26
This is followed by the seemingly novel appearance of preproNPY mRNA within the dentate gyrus granule cells and pyramidal cells of field CA1.
Transcription (appearance) of preproNPY mRNA in granule cells associated with pyramidal cell
7) Confidence 0.19 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.79 Pain Relevance 0.65

General Comments

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