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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP21A2) endoplasmic reticulum (CYP21A2)
CYP21A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 25 99.64 Very High Very High Very High
Serotonin 36 98.16 Very High Very High Very High
monoamine 13 95.80 Very High Very High Very High
depression 41 94.16 High High
Pain 2 52.20 Quite High
Neurotransmitter 2 30.32 Quite Low
antidepressant 35 8.72 Low Low
sSRI 41 5.00 Very Low Very Low Very Low
Duloxetine 33 5.00 Very Low Very Low Very Low
fluoxetine 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 48 94.16 High High
Depressive Disorder 3 91.20 High High
Disease 10 87.84 High High
Stress 10 79.88 Quite High
Suicidal Behaviour 1 73.36 Quite High
Major Depressive Disorder 27 60.48 Quite High
Congenital Anomalies 3 47.72 Quite Low
Cognitive Disorder 3 47.16 Quite Low
Constipation 5 39.80 Quite Low
Hypoactive Sexual Desire Disorder 2 39.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Noradrenaline depletion may be due to inhibition of tyrosine hydroxylase (see Figure 1), whereas reduced synthesis of serotonin may be due to depletion of dietary tryptophan or mutations of tryptophan hydroxylase.7,12 Given that reduced serotonin levels do not cause depression in all people, it is unclear if decreased serotonin synthesis is a cause or consequence of depression.9
Positive_regulation (due) of Negative_regulation (inhibition) of hydroxylase associated with depression, noradrenaline and serotonin
1) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 1.34 Pain Relevance 0.97
For example, the well-known human specific loss of CMAH (a CMP-sialic acid hydroxylase) [66] was not found by this analysis due to the strictness of TransMap gene model predictions, causing a valid CMAH gene model in the dog genome to be excluded because it featured a noncanonical GC-AG splice junction.
Neg (not) Positive_regulation (causing) of Negative_regulation (loss) of hydroxylase
2) Confidence 0.01 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2134963 Disease Relevance 0 Pain Relevance 0

General Comments

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